In vivo rat metabolism and pharmacokinetic studies of ginsenoside Rg3

Tianxiu Qian; Zongwei Cai; Ricky N. S. Wong; Nai Ki Mak; Zhi-Hong Jiang

doi:10.1016/j.jchromb.2004.11.036

In vivo rat metabolism and pharmacokinetic studies of ginsenoside Rg₃

Tianxiu Qian, Zongwei Cai^*, Ricky N. S. Wong, Nai Ki Mak, Zhi-Hong Jiang

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

104 Citations (Scopus)

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Abstract

Metabolism of an anti-tumor active component of Panax ginseng, ginsenoside (20R)-Rg₃, was studied for better understanding its pharmacokinetics in rat. LC-MS was used to determine Rg₃ and its metabolites in rat plasma, urine and feces samples. An average half-life of 18.5 min was obtained after the ginsenoside was intravenously dosed at 5 mg/kg. However, Rg ₃ was not detected in rat plasma collected after oral administration at 100 mg/kg. Only 0.97-1.15% Rg₃ of the dosed amount was determined in feces. Hydrolysis and oxygenated metabolites were detected and identified in feces collected after oral administration by using LC-MS and MS-MS.

Original language	English
Pages (from-to)	223-232
Number of pages	10
Journal	Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
Volume	816
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jchromb.2004.11.036
Publication status	Published - 25 Feb 2005

Scopus Subject Areas

Analytical Chemistry
Biochemistry
Clinical Biochemistry
Cell Biology

User-Defined Keywords

Ginsenoside Rg3
Rat metabolism
Pharmacokinetics
Metabolite identifications
LC–MS

Access to Document

10.1016/j.jchromb.2004.11.036

Full TextAccepted author manuscript, 11.4 MB

Cite this

@article{a0a337e9d7be4b28ac33eaf0243e2e42,

title = "In vivo rat metabolism and pharmacokinetic studies of ginsenoside Rg3",

abstract = "Metabolism of an anti-tumor active component of Panax ginseng, ginsenoside (20R)-Rg3, was studied for better understanding its pharmacokinetics in rat. LC-MS was used to determine Rg3 and its metabolites in rat plasma, urine and feces samples. An average half-life of 18.5 min was obtained after the ginsenoside was intravenously dosed at 5 mg/kg. However, Rg 3 was not detected in rat plasma collected after oral administration at 100 mg/kg. Only 0.97-1.15% Rg3 of the dosed amount was determined in feces. Hydrolysis and oxygenated metabolites were detected and identified in feces collected after oral administration by using LC-MS and MS-MS.",

keywords = "Ginsenoside Rg3, Rat metabolism, Pharmacokinetics, Metabolite identifications, LC–MS",

author = "Tianxiu Qian and Zongwei Cai and Wong, {Ricky N. S.} and Mak, {Nai Ki} and Zhi-Hong Jiang",

note = "Funding Information: This work was supported by a Faculty Research Grant provided by HKBU and earmarked grants (HKBU2017/02P and HKBU-1/00C) obtained from RGC, University Grants Committee of Hong Kong.",

year = "2005",

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doi = "10.1016/j.jchromb.2004.11.036",

language = "English",

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pages = "223--232",

journal = "Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences",

issn = "1570-0232",

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TY - JOUR

T1 - In vivo rat metabolism and pharmacokinetic studies of ginsenoside Rg3

AU - Qian, Tianxiu

AU - Cai, Zongwei

AU - Wong, Ricky N. S.

AU - Mak, Nai Ki

AU - Jiang, Zhi-Hong

N1 - Funding Information: This work was supported by a Faculty Research Grant provided by HKBU and earmarked grants (HKBU2017/02P and HKBU-1/00C) obtained from RGC, University Grants Committee of Hong Kong.

PY - 2005/2/25

Y1 - 2005/2/25

N2 - Metabolism of an anti-tumor active component of Panax ginseng, ginsenoside (20R)-Rg3, was studied for better understanding its pharmacokinetics in rat. LC-MS was used to determine Rg3 and its metabolites in rat plasma, urine and feces samples. An average half-life of 18.5 min was obtained after the ginsenoside was intravenously dosed at 5 mg/kg. However, Rg 3 was not detected in rat plasma collected after oral administration at 100 mg/kg. Only 0.97-1.15% Rg3 of the dosed amount was determined in feces. Hydrolysis and oxygenated metabolites were detected and identified in feces collected after oral administration by using LC-MS and MS-MS.

AB - Metabolism of an anti-tumor active component of Panax ginseng, ginsenoside (20R)-Rg3, was studied for better understanding its pharmacokinetics in rat. LC-MS was used to determine Rg3 and its metabolites in rat plasma, urine and feces samples. An average half-life of 18.5 min was obtained after the ginsenoside was intravenously dosed at 5 mg/kg. However, Rg 3 was not detected in rat plasma collected after oral administration at 100 mg/kg. Only 0.97-1.15% Rg3 of the dosed amount was determined in feces. Hydrolysis and oxygenated metabolites were detected and identified in feces collected after oral administration by using LC-MS and MS-MS.

KW - Ginsenoside Rg3

KW - Rat metabolism

KW - Pharmacokinetics

KW - Metabolite identifications

KW - LC–MS

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AN - SCOPUS:12444277341

SN - 1570-0232

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SP - 223

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JO - Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

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