In vivo rat metabolism and pharmacokinetic studies of ginsenoside Rg 3

Tianxiu Qian, Zongwei CAI*, Ricky N S WONG, Nai Ki MAK, Zhi Hong JIANG

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

90 Citations (Scopus)

Abstract

Metabolism of an anti-tumor active component of Panax ginseng, ginsenoside (20R)-Rg3, was studied for better understanding its pharmacokinetics in rat. LC-MS was used to determine Rg3 and its metabolites in rat plasma, urine and feces samples. An average half-life of 18.5 min was obtained after the ginsenoside was intravenously dosed at 5 mg/kg. However, Rg 3 was not detected in rat plasma collected after oral administration at 100 mg/kg. Only 0.97-1.15% Rg3 of the dosed amount was determined in feces. Hydrolysis and oxygenated metabolites were detected and identified in feces collected after oral administration by using LC-MS and MS-MS.

Original languageEnglish
Pages (from-to)223-232
Number of pages10
JournalJournal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
Volume816
Issue number1-2
DOIs
Publication statusPublished - 25 Feb 2005

Scopus Subject Areas

  • Analytical Chemistry
  • Biochemistry
  • Clinical Biochemistry
  • Cell Biology

User-Defined Keywords

  • Ginsenoside Rg
  • LC-MS
  • Metabolite identifications
  • Pharmacokinetics
  • Rat metabolism

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