In vivo chemoembolization and magnetic resonance imaging of liver tumors by using iron oxide nanoshell/doxorubicin/poly(vinyl alcohol) hybrid composites

Yi Xiang J. Wang, Xiao Ming Zhu, Qi Liang, Christopher H.K. Cheng, Wei Wang, Ken C F LEUNG

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)

Abstract

A hybrid composite made up of superparamagnetic iron oxide nanoshells encapsulating the anticancer drug doxorubicin and bound together by poly(vinyl alcohol) was developed. Transcatheter arterial delivery in an in vivo liver tumor model led to embolization of the liver tumor blood vessels. Embolization was followed by disassembly of the composite. The nanoshells were then able to pass through the leaky tumor vasculature into the tumor tissue, thereby leading to slow and sustained release of the drug. As well as being relatively noncytotoxic, the composite was responsive to magnetic resonance imaging, thus making it a potentially useful theranostic agent.

Original languageEnglish
Pages (from-to)4812-4815
Number of pages4
JournalAngewandte Chemie. International Edition
Volume53
Issue number19
DOIs
Publication statusPublished - 5 May 2014

Scopus Subject Areas

  • Catalysis
  • Chemistry(all)

User-Defined Keywords

  • antitumor agents
  • chemoembolization
  • drug delivery
  • iron oxide
  • liver cancer

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