In vivo antitumour activity of amphiphilic silicon(IV) phthalocyanine with axially ligated rhodamine B

Zhinxin Zhao; Roberto Gambari; Kenneth Ka Ho Lee; Stanton Hon Lung Kok; Raymond Siu Ming Wong; Fung Yi Lau; Johnny Cheuk On Tang; Kim Hung Lam; Chor Hing Cheng; Desmond Kwok Po Hau; Chung Hin Chui; Wai Yeung WONG; Rick W K Wong

doi:10.1016/j.bmcl.2013.02.049

In vivo antitumour activity of amphiphilic silicon(IV) phthalocyanine with axially ligated rhodamine B

Zhinxin Zhao
, Roberto Gambari
, Kenneth Ka Ho Lee
, Stanton Hon Lung Kok
, Raymond Siu Ming Wong
, Fung Yi Lau
, Johnny Cheuk On Tang
, Kim Hung Lam
, Chor Hing Cheng
, Desmond Kwok Po Hau
, Chung Hin Chui^*
, Wai Yeung WONG
, Rick W K Wong

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

6 Citations (Scopus)

Abstract

We explore the possible cellular cytotoxic activity of an amphiphilic silicon(IV) phthalocyanine with axially ligated rhodamine B under ambient light experimental environment as well as its in vivo antitumour potential using Hep3B hepatoma cell model. After loading into the Hep3B hepatoma cells, induction of cellular cytotoxicity and cell cycle arrest were detected. Strong growth inhibition of tumour xenograft together with significant tumour necrosis and limited toxicological effects exerted on the nude mice could be identified.

Original language	English
Pages (from-to)	2373-2376
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	23
Issue number	8
DOIs	https://doi.org/10.1016/j.bmcl.2013.02.049
Publication status	Published - 15 Apr 2013

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

User-Defined Keywords

Amphiphilic silicon(IV) phthalocyanine
Anticancer drugs
Hep3B
Nude mice xenograft
Rhodamine B
Toxicity

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10.1016/j.bmcl.2013.02.049

Cite this

Zhao, Z., Gambari, R., Lee, K. K. H., Kok, S. H. L., Wong, R. S. M., Lau, F. Y., Tang, J. C. O., Lam, K. H., Cheng, C. H., Hau, D. K. P., Chui, C. H., WONG, W. Y., & Wong, R. W. K. (2013). In vivo antitumour activity of amphiphilic silicon(IV) phthalocyanine with axially ligated rhodamine B. Bioorganic and Medicinal Chemistry Letters, 23(8), 2373-2376. https://doi.org/10.1016/j.bmcl.2013.02.049

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title = "In vivo antitumour activity of amphiphilic silicon(IV) phthalocyanine with axially ligated rhodamine B",

abstract = "We explore the possible cellular cytotoxic activity of an amphiphilic silicon(IV) phthalocyanine with axially ligated rhodamine B under ambient light experimental environment as well as its in vivo antitumour potential using Hep3B hepatoma cell model. After loading into the Hep3B hepatoma cells, induction of cellular cytotoxicity and cell cycle arrest were detected. Strong growth inhibition of tumour xenograft together with significant tumour necrosis and limited toxicological effects exerted on the nude mice could be identified.",

keywords = "Amphiphilic silicon(IV) phthalocyanine, Anticancer drugs, Hep3B, Nude mice xenograft, Rhodamine B, Toxicity",

author = "Zhinxin Zhao and Roberto Gambari and Lee, \{Kenneth Ka Ho\} and Kok, \{Stanton Hon Lung\} and Wong, \{Raymond Siu Ming\} and Lau, \{Fung Yi\} and Tang, \{Johnny Cheuk On\} and Lam, \{Kim Hung\} and Cheng, \{Chor Hing\} and Hau, \{Desmond Kwok Po\} and Chui, \{Chung Hin\} and WONG, \{Wai Yeung\} and Wong, \{Rick W K\}",

note = "Funding Information: Professor W.-Y. Wong and Professor W.-K. Wong acknowledge the support from Areas of Excellence Scheme, University Grants Committee of HKSAR, China (AoE/P-03/08). The work described in this paper was partially supported by a Grant from the Research Grants Council of the Hong Kong SAR, P.R. China ( HKBU 202509 and HKBU 202210 ) and a Grant from the Hong Kong Baptist University ( FRG2/09-10/58 ). Dr. C.-H. Chui acknowledges the offer of {\textquoteleft}Research Assistant Professor{\textquoteright} by Professor A.S.-C. Chan, Professor W.-K. Wong, Professor A.-P. Lu and Professor Z.-X. Bian from Hong Kong Baptist University.",

year = "2013",

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day = "15",

doi = "10.1016/j.bmcl.2013.02.049",

language = "English",

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AU - Zhao, Zhinxin

AU - Gambari, Roberto

AU - Lee, Kenneth Ka Ho

AU - Kok, Stanton Hon Lung

AU - Wong, Raymond Siu Ming

AU - Lau, Fung Yi

AU - Tang, Johnny Cheuk On

AU - Lam, Kim Hung

AU - Cheng, Chor Hing

AU - Hau, Desmond Kwok Po

AU - Chui, Chung Hin

AU - WONG, Wai Yeung

AU - Wong, Rick W K

N1 - Funding Information: Professor W.-Y. Wong and Professor W.-K. Wong acknowledge the support from Areas of Excellence Scheme, University Grants Committee of HKSAR, China (AoE/P-03/08). The work described in this paper was partially supported by a Grant from the Research Grants Council of the Hong Kong SAR, P.R. China ( HKBU 202509 and HKBU 202210 ) and a Grant from the Hong Kong Baptist University ( FRG2/09-10/58 ). Dr. C.-H. Chui acknowledges the offer of ‘Research Assistant Professor’ by Professor A.S.-C. Chan, Professor W.-K. Wong, Professor A.-P. Lu and Professor Z.-X. Bian from Hong Kong Baptist University.

PY - 2013/4/15

Y1 - 2013/4/15

N2 - We explore the possible cellular cytotoxic activity of an amphiphilic silicon(IV) phthalocyanine with axially ligated rhodamine B under ambient light experimental environment as well as its in vivo antitumour potential using Hep3B hepatoma cell model. After loading into the Hep3B hepatoma cells, induction of cellular cytotoxicity and cell cycle arrest were detected. Strong growth inhibition of tumour xenograft together with significant tumour necrosis and limited toxicological effects exerted on the nude mice could be identified.

AB - We explore the possible cellular cytotoxic activity of an amphiphilic silicon(IV) phthalocyanine with axially ligated rhodamine B under ambient light experimental environment as well as its in vivo antitumour potential using Hep3B hepatoma cell model. After loading into the Hep3B hepatoma cells, induction of cellular cytotoxicity and cell cycle arrest were detected. Strong growth inhibition of tumour xenograft together with significant tumour necrosis and limited toxicological effects exerted on the nude mice could be identified.

KW - Amphiphilic silicon(IV) phthalocyanine

KW - Anticancer drugs

KW - Hep3B

KW - Nude mice xenograft

KW - Rhodamine B

KW - Toxicity

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AN - SCOPUS:84875413479

SN - 0960-894X

VL - 23

SP - 2373

EP - 2376

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 8

ER -

In vivo antitumour activity of amphiphilic silicon(IV) phthalocyanine with axially ligated rhodamine B

Abstract

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