@article{c373c1784e824bada4318b102764675b,
title = "In vivo antitumour activity of amphiphilic silicon(IV) phthalocyanine with axially ligated rhodamine B",
abstract = "We explore the possible cellular cytotoxic activity of an amphiphilic silicon(IV) phthalocyanine with axially ligated rhodamine B under ambient light experimental environment as well as its in vivo antitumour potential using Hep3B hepatoma cell model. After loading into the Hep3B hepatoma cells, induction of cellular cytotoxicity and cell cycle arrest were detected. Strong growth inhibition of tumour xenograft together with significant tumour necrosis and limited toxicological effects exerted on the nude mice could be identified.",
keywords = "Amphiphilic silicon(IV) phthalocyanine, Anticancer drugs, Hep3B, Nude mice xenograft, Rhodamine B, Toxicity",
author = "Zhinxin Zhao and Roberto Gambari and Lee, {Kenneth Ka Ho} and Kok, {Stanton Hon Lung} and Wong, {Raymond Siu Ming} and Lau, {Fung Yi} and Tang, {Johnny Cheuk On} and Lam, {Kim Hung} and Cheng, {Chor Hing} and Hau, {Desmond Kwok Po} and Chui, {Chung Hin} and WONG, {Wai Yeung} and Wong, {Rick W K}",
note = "Funding Information: Professor W.-Y. Wong and Professor W.-K. Wong acknowledge the support from Areas of Excellence Scheme, University Grants Committee of HKSAR, China (AoE/P-03/08). The work described in this paper was partially supported by a Grant from the Research Grants Council of the Hong Kong SAR, P.R. China ( HKBU 202509 and HKBU 202210 ) and a Grant from the Hong Kong Baptist University ( FRG2/09-10/58 ). Dr. C.-H. Chui acknowledges the offer of {\textquoteleft}Research Assistant Professor{\textquoteright} by Professor A.S.-C. Chan, Professor W.-K. Wong, Professor A.-P. Lu and Professor Z.-X. Bian from Hong Kong Baptist University.",
year = "2013",
month = apr,
day = "15",
doi = "10.1016/j.bmcl.2013.02.049",
language = "English",
volume = "23",
pages = "2373--2376",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Ltd.",
number = "8",
}