In Vitro Reconstitution of Plant COPII Vesicles

Baiying Li*, Liwen Jiang

*Corresponding author for this work

Research output: Chapter in book/report/conference proceedingChapterpeer-review

Abstract

In vitro reconstitution studies enable the controllable and stepwise investigation of complicated biochemical processes. In yeast and mammals, in vitro reconstitution of COPII vesicles marked a pivotal point in characterizing the endoplasmic reticulum-to-Golgi anterograde trafficking route and revealed how vesicles mediate the selective and reliable transportation among topologically equivalent compartments. By providing the necessary physiological conditions in a cell-free environment, it enables the dissection of essential components required for the vesicle formation. To enrich and purify the small amount in vivo membrane-bounded compartments, it simplifies the evaluation of vesicle regulation by distinct external stimuli or upstream signals. Here, we describe the preparation of plant microsomes and cytosol for the reconstitution of plant COPII vesicles. Purified vesicles can be used for further biochemical or microscopical analyses.

Original languageEnglish
Title of host publicationPlant Protein Secretion
Subtitle of host publicationMethods and Protocols
EditorsLiwen Jiang, Jinbo Shen, Caiji Gao, Xiangfeng Wang
Place of PublicationNew York
PublisherHumana Press Inc.
Pages111-119
Number of pages9
Edition2nd
ISBN (Electronic)9781071640593
ISBN (Print)9781071640586, 9781071640616
DOIs
Publication statusPublished - 8 Aug 2024

Publication series

NameMethods in Molecular Biology
Volume2841
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Scopus Subject Areas

  • Molecular Biology
  • Genetics

User-Defined Keywords

  • Endomembrane trafficking
  • In vitro reconstitution
  • Plant COPII vesicle

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