In vitro imaging and Human Serum Albumin responsive dimeric lanthanide DO3A complex

Yuen On Fung, Wanqing Wu, Chi Tung Yeung, Hoi Kuan Kong, Kenny Kam Cheng Wong, Wai Sum Lo, Ga Lai Law, Ka-Leung WONG, Chi Kong Lau, Chi Sing LEE, Wing Tak Wong*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Two series of dimeric DO3A (1,4,7,10-tetraazacyclodecane-1,4,7-triacetate) lanthanide complexes (LnL1-LnL2, Ln = Eu, Gd, and Tb) have been synthesized with two different bridged chromophores. The X-ray structures of dimeric LnL1 (Ln = Gd and Tb) complexes show that each metal ion has nine coordination numbers with eight directly bound donor atoms of the ligand and one oxygen donor from the water molecule. Photophysical measurements indicate that the bridged antenna in LnL2 gives a higher efficiency than that of LnL1 and is responsive to the protein Human Serum Albumin (HSA), giving an f-f luminescence signal enhancement with a binding constant log K = 4.84. In vitro imaging of EuL1 and EuL2 in HeLa cells has been recorded, and EuL2 has demonstrated a higher rate of cellular uptake and low cytotoxicity (IC50 = 3 mM).

Original languageEnglish
Pages (from-to)5517-5525
Number of pages9
JournalInorganic Chemistry
Volume50
Issue number12
DOIs
Publication statusPublished - 20 Jun 2011

Scopus Subject Areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry

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