Improved tumour targeting with recombinant antibody–macrocycle conjugates

Timothy J. Norman; David Parker; Louise Royle; Alice Harrison; Pari Antoniw; David J. King

doi:10.1039/C39950001877

Improved tumour targeting with recombinant antibody–macrocycle conjugates

Timothy J. Norman
, David Parker^*
, Louise Royle
, Alice Harrison
, Pari Antoniw
, David J. King

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

33 Citations (Scopus)

Abstract

Linkage of a macrocyclic complexing agent to a spaced tri-maleimide allows formation of a recombinant trivalent antibody by reaction with a Δ-Cys Fab fragment of an engineered human antibody.

Original language	English
Pages (from-to)	1877-1878
Number of pages	2
Journal	Journal of the Chemical Society, Chemical Communications
Issue number	18
DOIs	https://doi.org/10.1039/C39950001877
Publication status	Published - Sept 1995

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title = "Improved tumour targeting with recombinant antibody–macrocycle conjugates",

abstract = "Linkage of a macrocyclic complexing agent to a spaced tri-maleimide allows formation of a recombinant trivalent antibody by reaction with a Δ-Cys Fab fragment of an engineered human antibody.",

author = "Norman, \{Timothy J.\} and David Parker and Louise Royle and Alice Harrison and Pari Antoniw and King, \{David J.\}",

year = "1995",

month = sep,

doi = "10.1039/C39950001877",

language = "English",

pages = "1877--1878",

journal = "Journal of the Chemical Society, Chemical Communications",

issn = "0022-4936",

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T1 - Improved tumour targeting with recombinant antibody–macrocycle conjugates

AU - Norman, Timothy J.

AU - Parker, David

AU - Royle, Louise

AU - Harrison, Alice

AU - Antoniw, Pari

AU - King, David J.

PY - 1995/9

Y1 - 1995/9

N2 - Linkage of a macrocyclic complexing agent to a spaced tri-maleimide allows formation of a recombinant trivalent antibody by reaction with a Δ-Cys Fab fragment of an engineered human antibody.

AB - Linkage of a macrocyclic complexing agent to a spaced tri-maleimide allows formation of a recombinant trivalent antibody by reaction with a Δ-Cys Fab fragment of an engineered human antibody.

UR - https://www.scopus.com/pages/publications/0029119793

U2 - 10.1039/C39950001877

DO - 10.1039/C39950001877

M3 - Journal article

AN - SCOPUS:0029119793

SN - 0022-4936

SP - 1877

EP - 1878

JO - Journal of the Chemical Society, Chemical Communications

JF - Journal of the Chemical Society, Chemical Communications

IS - 18

ER -

Improved tumour targeting with recombinant antibody–macrocycle conjugates

Abstract

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