Impressive near-infrared brightness and singlet oxygen generation from strategic lanthanide–porphyrin double-decker complexes in aqueous solution

Jing Xiang Zhang; Wai Lun Chan; Chen Xie; Yan Zhou; Ho Fai Chau; Partha Maity; George T. Harrison; Aram Amassian; Omar F. Mohammed; Peter A. Tanner; Rick W K WONG; Ka-Leung WONG

doi:10.1038/s41377-019-0155-9

Impressive near-infrared brightness and singlet oxygen generation from strategic lanthanide–porphyrin double-decker complexes in aqueous solution

Jing Xiang Zhang, Wai Lun Chan, Chen Xie, Yan Zhou, Ho Fai Chau, Partha Maity, George T. Harrison, Aram Amassian, Omar F. Mohammed, Peter A. Tanner^*, Rick W K WONG^*, Ka-Leung WONG^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

41 Citations (Scopus)

Abstract

Although lanthanide double-decker complexes with hetero-macrocyclic ligands as functional luminescent and magnetic materials have promising properties, their inferior water solubility has negated their biomedical applications. Herein, four water-soluble homoleptic lanthanide (Ln = Gd, Er, Yb and La) sandwiches with diethylene-glycol-disubstituted porphyrins (DD) are reported, with their structures proven by both quantum chemical calculations and scanning tunneling microscopy. Our findings demonstrate that the near-infrared emission intensity and singlet oxygen (¹O₂) quantum yields of YbDD and GdDD in aqueous media are higher than those of the reported capped lanthanide monoporphyrinato analogues, YbN and GdN; the brightness and luminescence lifetime in water of YbDD are greater than those of YbN. This work provides a new dimension for the future design and development of molecular theranostics-based water-soluble double-decker lanthanide bisporphyrinates.

Original language	English
Article number	46
Number of pages	10
Journal	Light: Science and Applications
Volume	8
Issue number	1
DOIs	https://doi.org/10.1038/s41377-019-0155-9
Publication status	Published - 22 May 2019

Scopus Subject Areas

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics

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Zhang, J. X., Chan, W. L., Xie, C., Zhou, Y., Chau, H. F., Maity, P., Harrison, G. T., Amassian, A., Mohammed, O. F., Tanner, P. A., WONG, R. W. K., & WONG, K.-L. (2019). Impressive near-infrared brightness and singlet oxygen generation from strategic lanthanide–porphyrin double-decker complexes in aqueous solution. Light: Science and Applications, 8(1), Article 46. https://doi.org/10.1038/s41377-019-0155-9

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title = "Impressive near-infrared brightness and singlet oxygen generation from strategic lanthanide–porphyrin double-decker complexes in aqueous solution",

abstract = "Although lanthanide double-decker complexes with hetero-macrocyclic ligands as functional luminescent and magnetic materials have promising properties, their inferior water solubility has negated their biomedical applications. Herein, four water-soluble homoleptic lanthanide (Ln = Gd, Er, Yb and La) sandwiches with diethylene-glycol-disubstituted porphyrins (DD) are reported, with their structures proven by both quantum chemical calculations and scanning tunneling microscopy. Our findings demonstrate that the near-infrared emission intensity and singlet oxygen (1O2) quantum yields of YbDD and GdDD in aqueous media are higher than those of the reported capped lanthanide monoporphyrinato analogues, YbN and GdN; the brightness and luminescence lifetime in water of YbDD are greater than those of YbN. This work provides a new dimension for the future design and development of molecular theranostics-based water-soluble double-decker lanthanide bisporphyrinates.",

author = "Zhang, {Jing Xiang} and Chan, {Wai Lun} and Chen Xie and Yan Zhou and Chau, {Ho Fai} and Partha Maity and Harrison, {George T.} and Aram Amassian and Mohammed, {Omar F.} and Tanner, {Peter A.} and WONG, {Rick W K} and Ka-Leung WONG",

note = "Funding Information: This work was supported by the Hong Kong Baptist University (HKBU), Hong Kong Research Grants Council (HKBU 12300117), and the HKBU-HKPolyU Joint Research Program (RC-ICRS/16-17/02). We thank Dr. Zhenyu Liu for his technical support in spectroscopic measurements and Professor Alex Granovsky for communication concerning the use of Firefly.",

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doi = "10.1038/s41377-019-0155-9",

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Zhang, JX, Chan, WL, Xie, C, Zhou, Y, Chau, HF, Maity, P, Harrison, GT, Amassian, A, Mohammed, OF, Tanner, PA, WONG, RWK & WONG, K-L 2019, 'Impressive near-infrared brightness and singlet oxygen generation from strategic lanthanide–porphyrin double-decker complexes in aqueous solution', Light: Science and Applications, vol. 8, no. 1, 46. https://doi.org/10.1038/s41377-019-0155-9

TY - JOUR

T1 - Impressive near-infrared brightness and singlet oxygen generation from strategic lanthanide–porphyrin double-decker complexes in aqueous solution

AU - Zhang, Jing Xiang

AU - Chan, Wai Lun

AU - Xie, Chen

AU - Zhou, Yan

AU - Chau, Ho Fai

AU - Maity, Partha

AU - Harrison, George T.

AU - Amassian, Aram

AU - Mohammed, Omar F.

AU - Tanner, Peter A.

AU - WONG, Rick W K

AU - WONG, Ka-Leung

N1 - Funding Information: This work was supported by the Hong Kong Baptist University (HKBU), Hong Kong Research Grants Council (HKBU 12300117), and the HKBU-HKPolyU Joint Research Program (RC-ICRS/16-17/02). We thank Dr. Zhenyu Liu for his technical support in spectroscopic measurements and Professor Alex Granovsky for communication concerning the use of Firefly.

PY - 2019/5/22

Y1 - 2019/5/22

N2 - Although lanthanide double-decker complexes with hetero-macrocyclic ligands as functional luminescent and magnetic materials have promising properties, their inferior water solubility has negated their biomedical applications. Herein, four water-soluble homoleptic lanthanide (Ln = Gd, Er, Yb and La) sandwiches with diethylene-glycol-disubstituted porphyrins (DD) are reported, with their structures proven by both quantum chemical calculations and scanning tunneling microscopy. Our findings demonstrate that the near-infrared emission intensity and singlet oxygen (1O2) quantum yields of YbDD and GdDD in aqueous media are higher than those of the reported capped lanthanide monoporphyrinato analogues, YbN and GdN; the brightness and luminescence lifetime in water of YbDD are greater than those of YbN. This work provides a new dimension for the future design and development of molecular theranostics-based water-soluble double-decker lanthanide bisporphyrinates.

AB - Although lanthanide double-decker complexes with hetero-macrocyclic ligands as functional luminescent and magnetic materials have promising properties, their inferior water solubility has negated their biomedical applications. Herein, four water-soluble homoleptic lanthanide (Ln = Gd, Er, Yb and La) sandwiches with diethylene-glycol-disubstituted porphyrins (DD) are reported, with their structures proven by both quantum chemical calculations and scanning tunneling microscopy. Our findings demonstrate that the near-infrared emission intensity and singlet oxygen (1O2) quantum yields of YbDD and GdDD in aqueous media are higher than those of the reported capped lanthanide monoporphyrinato analogues, YbN and GdN; the brightness and luminescence lifetime in water of YbDD are greater than those of YbN. This work provides a new dimension for the future design and development of molecular theranostics-based water-soluble double-decker lanthanide bisporphyrinates.

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DO - 10.1038/s41377-019-0155-9

M3 - Journal article

AN - SCOPUS:85066070697

SN - 2095-5545

VL - 8

JO - Light: Science and Applications

JF - Light: Science and Applications

IS - 1

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ER -

Impressive near-infrared brightness and singlet oxygen generation from strategic lanthanide–porphyrin double-decker complexes in aqueous solution

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