Implementation of macrocycle conjugated antibodies for tumour-targetting

David Parker; J. Richard Morphy; Karl Jankowski; Jonathan Cox

doi:10.1351/pac198961091637

Implementation of macrocycle conjugated antibodies for tumour-targetting

David Parker^*
, J. Richard Morphy
, Karl Jankowski
, Jonathan Cox

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

35 Citations (Scopus)

Abstract

Monoclonal antibodies may be selectively functionalised with macrocyclic ligands, permitting the transport of an imaging or cytotoxic metal radionuclide specifically to a tumour. Antibodies conjugated to [13] and [14]-membered tetraazamacrocycles allow ⁶⁴Cu or ⁶⁷Cu labelled antibody to be used for imaging or therapy.

Original language	English
Pages (from-to)	1637-1641
Number of pages	5
Journal	Pure and Applied Chemistry
Volume	61
Issue number	9
DOIs	https://doi.org/10.1351/pac198961091637
Publication status	Published - 1 Jan 1989

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being
SDG 9 Industry, Innovation, and Infrastructure

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10.1351/pac198961091637

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title = "Implementation of macrocycle conjugated antibodies for tumour-targetting",

abstract = "Monoclonal antibodies may be selectively functionalised with macrocyclic ligands, permitting the transport of an imaging or cytotoxic metal radionuclide specifically to a tumour. Antibodies conjugated to [13] and [14]-membered tetraazamacrocycles allow 64Cu or 67Cu labelled antibody to be used for imaging or therapy.",

author = "David Parker and Morphy, \{J. Richard\} and Karl Jankowski and Jonathan Cox",

note = "Publisher copyright: @ 1989 IUPAC",

year = "1989",

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doi = "10.1351/pac198961091637",

language = "English",

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T1 - Implementation of macrocycle conjugated antibodies for tumour-targetting

AU - Parker, David

AU - Morphy, J. Richard

AU - Jankowski, Karl

AU - Cox, Jonathan

PY - 1989/1/1

Y1 - 1989/1/1

N2 - Monoclonal antibodies may be selectively functionalised with macrocyclic ligands, permitting the transport of an imaging or cytotoxic metal radionuclide specifically to a tumour. Antibodies conjugated to [13] and [14]-membered tetraazamacrocycles allow 64Cu or 67Cu labelled antibody to be used for imaging or therapy.

AB - Monoclonal antibodies may be selectively functionalised with macrocyclic ligands, permitting the transport of an imaging or cytotoxic metal radionuclide specifically to a tumour. Antibodies conjugated to [13] and [14]-membered tetraazamacrocycles allow 64Cu or 67Cu labelled antibody to be used for imaging or therapy.

UR - https://www.scopus.com/pages/publications/0001250478

U2 - 10.1351/pac198961091637

DO - 10.1351/pac198961091637

M3 - Journal article

AN - SCOPUS:0001250478

SN - 0033-4545

VL - 61

SP - 1637

EP - 1641

JO - Pure and Applied Chemistry

JF - Pure and Applied Chemistry

IS - 9

ER -

Implementation of macrocycle conjugated antibodies for tumour-targetting

Abstract

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