Impact of Sulfur Fumigation on Ginger: Chemical and Biological Evidence

Wei-Hao Zhang, Han-Yan Luo, Jing Fang, Chen Liang Zhao, Kam-Chun Chan, Yui-Man Chan, Cai Xia Dong, Hu-Biao Chen, Zhong-Zhen Zhao, Song-Lin Li*, Jun Xu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

We previously found that sulfur fumigation, a commonly used controversial method for the post-harvest handling of ginger, induces the generation of a compound in ginger, which was speculated to be a sulfur-containing derivative of 6-shogaol based on its mass data. However, the chemical and biological properties of the compound remain unknown. As a follow-up study, here we report the chemical structure, systemic exposure, and anticancer activity of the compound. Chromatographic separation, nuclear magnetic resonance analysis, and chemical synthesis structurally elucidated the compound as 6-gingesulfonic acid. Pharmacokinetics in rats found that 6-gingesulfonic acid was more slowly absorbed and eliminated, with more prototypes existing in the blood than 6-shogaol. Metabolism profiling indicated that the two compounds produced qualitatively and quantitatively different metabolites. It was further found that 6-gingesulfonic acid exerted significantly weaker antiproliferative activity on tumor cells than 6-shogaol. The data provide chemical and biological evidence that sulfur fumigation may impair the healthcare functions of ginger.
Original languageEnglish
Number of pages10
JournalJournal of Agricultural and Food Chemistry
DOIs
Publication statusE-pub ahead of print - 21 Sep 2022

User-Defined Keywords

  • ginger
  • sulfur fumigation
  • 6-gingesulfonic acid
  • 6-shogaol
  • systemic exposure
  • anticancer

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