Impact of Subjective and Objective Sleep Quality on Peptic Ulcer Rebleeding in Older Adults

Boye Fang, Danyu Li, Huiying Liu, Shuyan Yang, Ruirui Xu, Gengzhen Chen, Jian Hu*

*Corresponding author for this work

    Research output: Contribution to journalJournal articlepeer-review

    1 Citation (Scopus)



    This study aimed to examine the association of subjective and objective sleep quality with subsequent peptic ulcer rebleeding among older patients. 


    Of 1196 older patients with peptic ulcer bleeding (PUB) recruited from 12 grade A hospitals in the People's Republic of China, 1106 achieved full recovery from PUB, and they were followed up for up to 30 days. Using multiple measures at 1-week intervals, patients who presented PUB symptoms were invited to have an esophagogastroduodenoscopy examination. Subjective sleep quality was measured using the Pittsburgh Sleep Quality Index. Objective sleep quality domains were measured using an accelerometer, including sleep onset latency, sleep efficiency, total sleep time, and the number of awakenings. 


    This study documented a 30-day cumulative ulcer rebleeding rate of 15.3%. Multivariate analyses showed that longer sleep onset latency (hazard ratio [HR] = 2.136 [1.336-2.558]) and more nighttime awakenings (HR = 1.698 [1.169-2.666]) increased the risk of ulcer rebleeding. However, a longer total sleep time (HR = 0.768 [0.698-0.887]) and better sleep efficiency (HR = 0.795 [0.682-0.975]) protected against ulcer rebleeding. Older patients who perceived poorer sleep quality were also more likely to experience ulcer rebleeding (HR = 2.295 [1.352-3.925]). 


    The present results highlight the importance of proper treatment and prevention of sleep problems in older adults after successful PUB treatment. Our results, if replicable in future studies with more rigorous design and representative samples, might shed light on the etiology of ulcer rebleeding and suggest new pathways for preventing this disease.

    Original languageEnglish
    Pages (from-to)995-1003
    Number of pages9
    JournalPsychosomatic Medicine
    Issue number9
    Publication statusPublished - Nov 2021

    Scopus Subject Areas

    • Applied Psychology
    • Psychiatry and Mental health

    User-Defined Keywords

    • poor sleep quality
    • peptic ulcer rebleeding
    • older patients


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