Impact of a 21-km Run on Cardiac Biomarkers in Adolescent Runners

Frank H K FU*, Jinlei Nie, Keith George, Tom K K TONG, Hua Lin, Qingde Shi

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

15 Citations (Scopus)


Post-exercise cardiac biomarker release has been widely reported in adult athlete groups but limited data is available for adolescents. We assessed the impact of a 21-km run on cardiac biomarkers in adolescent athletes and uniquely assessed N-terminal pro-brain natriuretic peptide (NT-pro-BNP) and its potential association with serum cardiac troponin T (cTnT) appearance. NT-pro-BNP and cTnT were measured in 17 male adolescent runners (age, 16.5 ± 1.6 years) before, immediately after and 4 hours after a 21-km run. Post-exercise, both cTnT (median, range: 0.12, <0.01-1.33 ng·mL-1) and NT-pro-BNP (median, range: 132.6, 73.8-370.6 pg·mL-1) were elevated (p < 0.05) compared to pre-exercise (median, range: cTnT, < 0.01, < 0.01-0.02 ng·mL-1; NT-pro-BNP, 113.8, 39.1-240.6 pg·mL-1). There was no significant correlation between delta NT-pro-BNP with peak post-exercise cTnT (r = 0.29, p > 0.05). Further, there was no significant difference in peak post-exercise cTnT levels (median, range: 0.10, 0.02-1.33 vs. 0.13, 0.02-0.35 ng·mL-1, respectively, p > 0.05) between the subjects with higher delta pre-post NT-pro-BNP values (range, 62.9-186.1 pg·mL-1, n = 8) and the other subjects with lower delta pre-post NT-pro-BNP values (range, 8.3-55.3 pg·mL-1, n = 9). The findings suggest that during recovery from a 21-km run, both serum cTnT and NT-pro-BNP were elevated in adolescent athletes, but no significant relationship existed between increases in both biomarkers. This supports the contention that exercise-induced cTnT and NT-pro-BNP release are largely independently mediated phenomena.

Original languageEnglish
Pages (from-to)61-66
Number of pages6
JournalJournal of Exercise Science and Fitness
Issue number2
Publication statusPublished - 2010

Scopus Subject Areas

  • Physical Therapy, Sports Therapy and Rehabilitation
  • Public Health, Environmental and Occupational Health

User-Defined Keywords

  • Brain natriuretic peptide
  • Cardiac troponin T
  • Endurance exercise
  • Junior athletes


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