Impact and Advances in the Role of Bacterial Extracellular Vesicles in Neurodegenerative Disease and Its Therapeutics

Ashok Iyaswamy*, Kejia Lu, Xin Jie Guan, Yuxuan Kan, Chengfu Su, Jia Liu, Ravindran Jaganathan, Karthick Vasudevan, Jeyakumari Paul, Abhimanyu Thakur*, Min Li*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

9 Citations (Scopus)


Bacterial Extracellular Vesicles (BEVs) possess the capability of intracellular interactions with other cells, and, hence, can be utilized as an efficient cargo for worldwide delivery of therapeutic substances such as monoclonal antibodies, proteins, plasmids, siRNA, and small molecules for the treatment of neurodegenerative diseases (NDs). BEVs additionally possess a remarkable capacity for delivering these therapeutics across the blood–brain barrier to treat Alzheimer’s disease (AD). This review summarizes the role and advancement of BEVs for NDs, AD, and their treatment. Additionally, it investigates the critical BEV networks in the microbiome–gut–brain axis, their defensive and offensive roles in NDs, and their interaction with NDs. Furthermore, the part of BEVs in the neuroimmune system and their interference with ND, as well as the risk factors made by BEVs in the autophagy–lysosomal pathway and their potential outcomes on ND, are all discussed. To conclude, this review aims to gain a better understanding of the credentials of BEVs in NDs and possibly discover new therapeutic strategies.

Original languageEnglish
Article number2056
Number of pages13
Issue number7
Publication statusPublished - Jul 2023

Scopus Subject Areas

  • Medicine (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)

User-Defined Keywords

  • Alzheimer’s disease
  • bacterial extracellular vesicles
  • nanocarriers
  • neurodegenerative disease
  • therapeutics


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