Immunosuppressive decalin derivatives from red yeast rice

Lin Zhu, Jing Guang Lu, Ting Li, Guo Yuan Zhu, Simon Q B HAN, Wendy W L HSIAO, Liang LIU*, Zhi Hong JIANG

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Five new decalin derivatives (1-5), together with two known compounds (6 and 7), were isolated from the ethyl acetate extract of red yeast rice. Their structures were elucidated by means of NMR and mass spectroscopic analyses. Monascusic lactone A (1) is the first reported naturally occurring decalin derivative possessing a spiro lactone at the C-1 position. The immunosuppressive effects of all these isolates (1-7) on human T cell proliferation were investigated, and all, especially monascusic acids B (2), C (3), D (4), and A (6) and heptaketide (7), suppressed human T cell proliferation in a dose-dependent manner from 10 to 100 μM. This is the first report on the immunosuppressive activity of decalin derivatives.

Original languageEnglish
Pages (from-to)567-571
Number of pages5
JournalJournal of Natural Products
Volume75
Issue number4
DOIs
Publication statusPublished - 27 Apr 2012

Scopus Subject Areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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