Immunomodulatory potential of natural products from herbal medicines as immune checkpoints inhibitors: Helping to fight against cancer via multiple targets

Zhangfeng Zhong; Chi Teng Vong; Feiyu Chen; Horyue Tan; Cheng Zhang; Ning Wang; Liao Cui; Yitao Wang; Yibin Feng

doi:10.1002/med.21876

Immunomodulatory potential of natural products from herbal medicines as immune checkpoints inhibitors: Helping to fight against cancer via multiple targets

Zhangfeng Zhong, Chi Teng Vong, Feiyu Chen, Horyue Tan, Cheng Zhang, Ning Wang, Liao Cui, Yitao Wang^*, Yibin Feng^*

^*Corresponding author for this work

Centre for Chinese Herbal Medicine Drug Development Limited

Research output: Contribution to journal › Review article › peer-review

58 Citations (Scopus)

Abstract

Immunotherapy sheds new light to cancer treatment and is satisfied by cancer patients. However, immunotoxicity, single-source antibodies, and single-targeting stratege are potential challenges to the success of cancer immunotherapy. A huge number of promising lead compounds for cancer treatment are of natural origin from herbal medicines. The application of natural products from herbal medicines that have immunomodulatory properties could alter the landscape of immunotherapy drastically. The present study summarizes current medication for cancer immunotherapy and discusses the potential chemicals from herbal medicines as immune checkpoint inhibitors that have a broad range of immunomodulatory effects. Therefore, this review provides valuable insights into the efficacy and mechanism of actions of cancer immunotherapies, including natural products and combined treatment with immune checkpoint inhibitors, which could confer an improved clinical outcome for cancer treatment.

Original language	English
Pages (from-to)	1246-1279
Number of pages	34
Journal	Medicinal Research Reviews
Volume	42
Issue number	3
Early online date	14 Jan 2022
DOIs	https://doi.org/10.1002/med.21876
Publication status	Published - May 2022

Scopus Subject Areas

Drug Discovery
Molecular Medicine
Pharmacology

User-Defined Keywords

cancer immunotherapy
herbal medicine
immune response
immune-checkpoint blockade
natural products
Neoplasms/therapy
Immune Checkpoint Inhibitors
Immunomodulation
Humans
Immunotherapy
Biological Products/pharmacology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/med.21876

Cite this

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abstract = "Immunotherapy sheds new light to cancer treatment and is satisfied by cancer patients. However, immunotoxicity, single-source antibodies, and single-targeting stratege are potential challenges to the success of cancer immunotherapy. A huge number of promising lead compounds for cancer treatment are of natural origin from herbal medicines. The application of natural products from herbal medicines that have immunomodulatory properties could alter the landscape of immunotherapy drastically. The present study summarizes current medication for cancer immunotherapy and discusses the potential chemicals from herbal medicines as immune checkpoint inhibitors that have a broad range of immunomodulatory effects. Therefore, this review provides valuable insights into the efficacy and mechanism of actions of cancer immunotherapies, including natural products and combined treatment with immune checkpoint inhibitors, which could confer an improved clinical outcome for cancer treatment.",

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author = "Zhangfeng Zhong and Vong, {Chi Teng} and Feiyu Chen and Horyue Tan and Cheng Zhang and Ning Wang and Liao Cui and Yitao Wang and Yibin Feng",

note = "Funding Information: This study was partially supported by Wong's donation (Grant No. 200006276), a donation from the Gaia Family Trust of New Zealand (Grant No. 200007008), the Research Grants Committee (RGC) of Hong Kong, HKSAR (Grant No. 17121419), the Health and Medical Research Fund (Project Codes 16172751), the China Postdoctoral Science Foundation Funded Project (2017M622811), the Natural Science Foundation of Guangdong Province, China (2018A030310226 and 2020A1515010922), and the Macao Science and Technology Development Fund (FDCT 007/2020/ALC). This research is also funded by the Hong Kong Scholars Program. Publisher Copyright: {\textcopyright} 2022 The Authors. Medicinal Research Reviews published by Wiley Periodicals LLC.",

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AU - Tan, Horyue

AU - Zhang, Cheng

AU - Wang, Ning

AU - Cui, Liao

AU - Wang, Yitao

AU - Feng, Yibin

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Immunomodulatory potential of natural products from herbal medicines as immune checkpoints inhibitors: Helping to fight against cancer via multiple targets

Abstract

Scopus Subject Areas

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UN SDGs

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