Immunomodulatory potential of natural products from herbal medicines as immune checkpoints inhibitors: Helping to fight against cancer via multiple targets

Zhangfeng Zhong, Chi Teng Vong, Feiyu Chen, Horyue Tan, Cheng Zhang, Ning Wang, Liao Cui, Yitao Wang*, Yibin Feng*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

36 Citations (Scopus)

Abstract

Immunotherapy sheds new light to cancer treatment and is satisfied by cancer patients. However, immunotoxicity, single-source antibodies, and single-targeting stratege are potential challenges to the success of cancer immunotherapy. A huge number of promising lead compounds for cancer treatment are of natural origin from herbal medicines. The application of natural products from herbal medicines that have immunomodulatory properties could alter the landscape of immunotherapy drastically. The present study summarizes current medication for cancer immunotherapy and discusses the potential chemicals from herbal medicines as immune checkpoint inhibitors that have a broad range of immunomodulatory effects. Therefore, this review provides valuable insights into the efficacy and mechanism of actions of cancer immunotherapies, including natural products and combined treatment with immune checkpoint inhibitors, which could confer an improved clinical outcome for cancer treatment.
Original languageEnglish
Pages (from-to)1246-1279
Number of pages34
JournalMedicinal Research Reviews
Volume42
Issue number3
Early online date14 Jan 2022
DOIs
Publication statusPublished - May 2022

Scopus Subject Areas

  • Drug Discovery
  • Molecular Medicine
  • Pharmacology

User-Defined Keywords

  • cancer immunotherapy
  • herbal medicine
  • immune response
  • immune-checkpoint blockade
  • natural products
  • Neoplasms/therapy
  • Immune Checkpoint Inhibitors
  • Immunomodulation
  • Humans
  • Immunotherapy
  • Biological Products/pharmacology

Fingerprint

Dive into the research topics of 'Immunomodulatory potential of natural products from herbal medicines as immune checkpoints inhibitors: Helping to fight against cancer via multiple targets'. Together they form a unique fingerprint.

Cite this