Immunomodulatory Effect of Methimazole on Inbred Mice

Wing Keung Liu*, Nai Ki MAK, Chuen Chuen Wong

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

The effects of antithyroid drug, methimazole (MMI, 1-methyl-2-mercaptoimidazole), on the immune system of inbred mice, C57BL/6, were studied. The proliferative response of splenic lymphocytes to concanavalin A (Con A) and allogeneic stimulator cells was reduced when the mice were provided with 0.1 % MMI in tap water ad libitum for two to four weeks. The reduction of proliferative response was correlated with a lower frequency of proliferative spleen cells in the MMI-treated mice. The ability to produce macrophage activating factor of these spleen cells and the levels of hemolytic plaque-forming cells were also reduced. However, the mitogenic response of the splenic lymphocytes to lipopolysaccharide (LPS) was enhanced. In order to investigate whether the impaired cell-mediated and humoral immune systems would increase the susceptibility of the MMI-treated animal to the growth of tumor cells, mice were challenged with a lethal dose of Moloney virus-induced T cell lymphoma of C57BL/6 mice (MBL-2). The time required for 50 % of the animals to die was reduced from 15 days for the normal mice to 10 days for the MMI-treated mice.

Original languageEnglish
Pages (from-to)23-32
Number of pages10
JournalImmunobiology
Volume180
Issue number1
DOIs
Publication statusPublished - 1989

Scopus Subject Areas

  • Immunology and Allergy
  • Immunology
  • Hematology

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