ent-kaurane diterpenoids from the leaves of Isodon xerophilus

Sheng Hong Li, Xue Mei Niu, Li Yan Peng, Hong Jie Zhang, Ping Yao, Han Dong Sun*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

15 Citations (Scopus)


From the ethanolic extract of the leaves of Isodon xerophilus, three new ent-kaurane diterpenoids named xerophilusins L-N (1-3), together with three known ones designated as rabdoternin A (4), longikaurin F (5) and ponicidin (6), were isolated and structurally elucidated. Compound 6 demonstrated most potent cytotoxic activity against K562 and T24 human tumor cell lines with IC50 = 0.09 and 0.32 μg/ml, respectively.

Original languageEnglish
Pages (from-to)946-948
Number of pages3
JournalPlanta Medica
Issue number10
Publication statusPublished - 1 Oct 2002

Scopus Subject Areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry


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