ent-kaurane diterpenoids from the leaves of Isodon xerophilus

Sheng Hong Li; Xue Mei Niu; Li Yan Peng; Hong Jie Zhang; Ping Yao; Han Dong Sun

doi:10.1055/s-2002-34926

ent-kaurane diterpenoids from the leaves of Isodon xerophilus

Sheng Hong Li, Xue Mei Niu, Li Yan Peng, Hong Jie Zhang, Ping Yao, Han Dong Sun^*

^*Corresponding author for this work

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Journal article › peer-review

16 Citations (Scopus)

Abstract

From the ethanolic extract of the leaves of Isodon xerophilus, three new ent-kaurane diterpenoids named xerophilusins L-N (1-3), together with three known ones designated as rabdoternin A (4), longikaurin F (5) and ponicidin (6), were isolated and structurally elucidated. Compound 6 demonstrated most potent cytotoxic activity against K562 and T24 human tumor cell lines with IC₅₀ = 0.09 and 0.32 μg/ml, respectively.

Original language	English
Pages (from-to)	946-948
Number of pages	3
Journal	Planta Medica
Volume	68
Issue number	10
DOIs	https://doi.org/10.1055/s-2002-34926
Publication status	Published - 1 Oct 2002

Scopus Subject Areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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title = "ent-kaurane diterpenoids from the leaves of Isodon xerophilus",

abstract = "From the ethanolic extract of the leaves of Isodon xerophilus, three new ent-kaurane diterpenoids named xerophilusins L-N (1-3), together with three known ones designated as rabdoternin A (4), longikaurin F (5) and ponicidin (6), were isolated and structurally elucidated. Compound 6 demonstrated most potent cytotoxic activity against K562 and T24 human tumor cell lines with IC50 = 0.09 and 0.32 μg/ml, respectively.",

author = "Li, {Sheng Hong} and Niu, {Xue Mei} and Peng, {Li Yan} and Zhang, {Hong Jie} and Ping Yao and Sun, {Han Dong}",

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T1 - ent-kaurane diterpenoids from the leaves of Isodon xerophilus

AU - Li, Sheng Hong

AU - Niu, Xue Mei

AU - Peng, Li Yan

AU - Zhang, Hong Jie

AU - Yao, Ping

AU - Sun, Han Dong

PY - 2002/10/1

Y1 - 2002/10/1

N2 - From the ethanolic extract of the leaves of Isodon xerophilus, three new ent-kaurane diterpenoids named xerophilusins L-N (1-3), together with three known ones designated as rabdoternin A (4), longikaurin F (5) and ponicidin (6), were isolated and structurally elucidated. Compound 6 demonstrated most potent cytotoxic activity against K562 and T24 human tumor cell lines with IC50 = 0.09 and 0.32 μg/ml, respectively.

AB - From the ethanolic extract of the leaves of Isodon xerophilus, three new ent-kaurane diterpenoids named xerophilusins L-N (1-3), together with three known ones designated as rabdoternin A (4), longikaurin F (5) and ponicidin (6), were isolated and structurally elucidated. Compound 6 demonstrated most potent cytotoxic activity against K562 and T24 human tumor cell lines with IC50 = 0.09 and 0.32 μg/ml, respectively.

UR - http://www.scopus.com/inward/record.url?scp=0036775630&partnerID=8YFLogxK

U2 - 10.1055/s-2002-34926

DO - 10.1055/s-2002-34926

M3 - Journal article

C2 - 12391566

AN - SCOPUS:0036775630

SN - 0032-0943

VL - 68

SP - 946

EP - 948

JO - Planta Medica

JF - Planta Medica

IS - 10

ER -

ent-kaurane diterpenoids from the leaves of Isodon xerophilus

Abstract

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