Identifying projected clusters from gene expression profiles

Kevin Y. Yip*, David W. Cheung, Michael K. Ng, Kei Hoi Cheung

*Corresponding author for this work

Research output: Chapter in book/report/conference proceedingConference proceedingpeer-review

3 Citations (Scopus)

Abstract

In microarray gene expression data, clusters may hide in subspaces. Traditional clustering algorithms that make use of similarity measurements in the full input space may fail to detect the clusters. In recent years a number of algorithms have been proposed to identify this kind of projected clusters, but many of them rely on some critical parameters whose proper values are hard for users to determine. In this paper a new algorithm that dynamically adjusts its internal thresholds is proposed. It has a low dependency on user parameters while allowing users to input some domain knowledge should they be available. Experimental results show that the algorithm is capable of identifying some interesting projected clusters from real microarray data.

Original languageEnglish
Title of host publicationProceedings - Fourth IEEE Symposium on Bioinformatics and Bioengineering, BIBE 2004
EditorsDeeber Azada
PublisherIEEE
Pages259-266
Number of pages8
ISBN (Print)0769521738, 9780769521732
DOIs
Publication statusPublished - 21 May 2004
EventProceedings - Fourth IEEE Symposium on Bioinformatics and Bioengineering, BIBE 2004 - Taichung, Taiwan, Province of China
Duration: 19 May 200421 May 2004

Publication series

NameProceedings - IEEE Symposium on Bioinformatics and Bioengineering, BIBE
PublisherIEEE

Conference

ConferenceProceedings - Fourth IEEE Symposium on Bioinformatics and Bioengineering, BIBE 2004
Country/TerritoryTaiwan, Province of China
CityTaichung
Period19/05/0421/05/04

Scopus Subject Areas

  • General Engineering

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