Identification of natural product Fonsecin B as a stabilizing ligand of c-mycG-quadruplexDNA by high-throughput virtual screening

Ho-Man Lee; Daniel Shiu-Hin Chan; Fang Yang; Ho-Yu Lam; Siu-Cheong Yan; Chi-Ming Che; Dik-Lung Ma; Chung-Hang Leung

doi:10.1039/b926359d

Identification of natural product Fonsecin B as a stabilizing ligand of c-mycG-quadruplexDNA by high-throughput virtual screening

Ho-Man Lee, Daniel Shiu-Hin Chan, Fang Yang, Ho-Yu Lam, Siu-Cheong Yan, Chi-Ming Che, Dik-Lung Ma^*, Chung-Hang Leung

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

81 Citations (Scopus)

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Abstract

Fonsecin B has been identified as stabilizing ligand of c-myc G-quadruplex DNA using high-throughput virtual screening of a natural product database, and inhibited Taq polymerase-mediated DNA extension in vitro through stabilization of the G-quadruplex secondary structure.

Original language	English
Pages (from-to)	4680-4682
Number of pages	3
Journal	Chemical Communications
Volume	46
Issue number	26
Early online date	9 Apr 2010
DOIs	https://doi.org/10.1039/b926359d
Publication status	Published - Jul 2010

Scopus Subject Areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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title = "Identification of natural product Fonsecin B as a stabilizing ligand of c-mycG-quadruplexDNA by high-throughput virtual screening",

abstract = "Fonsecin B has been identified as stabilizing ligand of c-myc G-quadruplex DNA using high-throughput virtual screening of a natural product database, and inhibited Taq polymerase-mediated DNA extension in vitro through stabilization of the G-quadruplex secondary structure.",

author = "Ho-Man Lee and Chan, {Daniel Shiu-Hin} and Fang Yang and Ho-Yu Lam and Siu-Cheong Yan and Chi-Ming Che and Dik-Lung Ma and Chung-Hang Leung",

note = "This work is supported by the Area of Excellence Scheme established under the University Grants Committee of the Hong Kong Special Administrative Region, China (AoE/P-10/01), the University of Hong Kong (University Development Fund), the University of Hong Kong Seed Funding Programme for Applied Research, and the University of Hong Kong Seed Funding Programme for Basic Research.",

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AU - Lee, Ho-Man

AU - Chan, Daniel Shiu-Hin

AU - Yang, Fang

AU - Lam, Ho-Yu

AU - Yan, Siu-Cheong

AU - Che, Chi-Ming

AU - Ma, Dik-Lung

AU - Leung, Chung-Hang

N1 - This work is supported by the Area of Excellence Scheme established under the University Grants Committee of the Hong Kong Special Administrative Region, China (AoE/P-10/01), the University of Hong Kong (University Development Fund), the University of Hong Kong Seed Funding Programme for Applied Research, and the University of Hong Kong Seed Funding Programme for Basic Research.

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N2 - Fonsecin B has been identified as stabilizing ligand of c-myc G-quadruplex DNA using high-throughput virtual screening of a natural product database, and inhibited Taq polymerase-mediated DNA extension in vitro through stabilization of the G-quadruplex secondary structure.

AB - Fonsecin B has been identified as stabilizing ligand of c-myc G-quadruplex DNA using high-throughput virtual screening of a natural product database, and inhibited Taq polymerase-mediated DNA extension in vitro through stabilization of the G-quadruplex secondary structure.

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M3 - Journal article

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JO - Chemical Communications

JF - Chemical Communications

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ER -

Identification of natural product Fonsecin B as a stabilizing ligand of c-mycG-quadruplexDNA by high-throughput virtual screening

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