Identification of natural product Fonsecin B as a stabilizing ligand of c-mycG-quadruplexDNA by high-throughput virtual screening

Ho-Man Lee, Daniel Shiu-Hin Chan, Fang Yang, Ho-Yu Lam, Siu-Cheong Yan, Chi-Ming Che, Dik-Lung Ma*, Chung-Hang Leung

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

83 Citations (Scopus)
22 Downloads (Pure)

Abstract

Fonsecin B has been identified as stabilizing ligand of c-myc G-quadruplex DNA using high-throughput virtual screening of a natural product database, and inhibited Taq polymerase-mediated DNA extension in vitro through stabilization of the G-quadruplex secondary structure.

Original languageEnglish
Pages (from-to)4680-4682
Number of pages3
JournalChemical Communications
Volume46
Issue number26
Early online date9 Apr 2010
DOIs
Publication statusPublished - Jul 2010

Scopus Subject Areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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