Identification of four urea adducts of andrographolide in humans

Liang Cui, Wan Chan, Feng Qiu, Zongwei CAI, Xinsheng Yao*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Andrographolide is a component of a famous traditional Chinese herbal medicine Andrographis paniculate (Burm) Nees. In this study, the metabolites of andrographolide in human urine after oral administration were investigated. Four urea adducts were isolated by chromatography methods and identified by high-resolution mass spectra, 1 D and 2D NMR spectroscopy.

Original languageEnglish
Pages (from-to)261-268
Number of pages8
JournalDrug Metabolism Letters
Volume2
Issue number4
DOIs
Publication statusPublished - 2008

Scopus Subject Areas

  • Pharmaceutical Science
  • Clinical Biochemistry
  • Biochemistry, medical
  • Pharmacology (medical)

User-Defined Keywords

  • Andrographolide
  • HRSI-MS
  • Human urine
  • Metabolites
  • NMR
  • Urea adducts

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