Identification of four urea adducts of andrographolide in humans

Liang Cui; Wan Chan; Feng Qiu; Zongwei CAI; Xinsheng Yao

doi:10.2174/187231208786734148

Identification of four urea adducts of andrographolide in humans

Liang Cui, Wan Chan, Feng Qiu, Zongwei CAI, Xinsheng Yao^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

20 Citations (Scopus)

Abstract

Andrographolide is a component of a famous traditional Chinese herbal medicine Andrographis paniculate (Burm) Nees. In this study, the metabolites of andrographolide in human urine after oral administration were investigated. Four urea adducts were isolated by chromatography methods and identified by high-resolution mass spectra, 1 D and 2D NMR spectroscopy.

Original language	English
Pages (from-to)	261-268
Number of pages	8
Journal	Drug Metabolism Letters
Volume	2
Issue number	4
DOIs	https://doi.org/10.2174/187231208786734148
Publication status	Published - 2008

Scopus Subject Areas

Pharmaceutical Science
Clinical Biochemistry
Biochemistry, medical
Pharmacology (medical)

User-Defined Keywords

Andrographolide
HRSI-MS
Human urine
Metabolites
NMR
Urea adducts

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2174/187231208786734148

Cite this

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abstract = "Andrographolide is a component of a famous traditional Chinese herbal medicine Andrographis paniculate (Burm) Nees. In this study, the metabolites of andrographolide in human urine after oral administration were investigated. Four urea adducts were isolated by chromatography methods and identified by high-resolution mass spectra, 1 D and 2D NMR spectroscopy.",

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author = "Liang Cui and Wan Chan and Feng Qiu and Zongwei CAI and Xinsheng Yao",

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AU - Cui, Liang

AU - Chan, Wan

AU - Qiu, Feng

AU - CAI, Zongwei

AU - Yao, Xinsheng

PY - 2008

Y1 - 2008

N2 - Andrographolide is a component of a famous traditional Chinese herbal medicine Andrographis paniculate (Burm) Nees. In this study, the metabolites of andrographolide in human urine after oral administration were investigated. Four urea adducts were isolated by chromatography methods and identified by high-resolution mass spectra, 1 D and 2D NMR spectroscopy.

AB - Andrographolide is a component of a famous traditional Chinese herbal medicine Andrographis paniculate (Burm) Nees. In this study, the metabolites of andrographolide in human urine after oral administration were investigated. Four urea adducts were isolated by chromatography methods and identified by high-resolution mass spectra, 1 D and 2D NMR spectroscopy.

KW - Andrographolide

KW - HRSI-MS

KW - Human urine

KW - Metabolites

KW - NMR

KW - Urea adducts

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U2 - 10.2174/187231208786734148

DO - 10.2174/187231208786734148

M3 - Journal article

C2 - 19356103

AN - SCOPUS:65249125137

SN - 1872-3128

VL - 2

SP - 261

EP - 268

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JF - Drug Metabolism Letters

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ER -

Identification of four urea adducts of andrographolide in humans

Abstract

Scopus Subject Areas

User-Defined Keywords

UN SDGs

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