@article{6905d6b079d04fc49ae8dbd08590fd3d,
title = "Identification of an iridium(III) complex with anti-bacterial and anti-cancer activity",
abstract = "Group 9 transition metal complexes have been widely explored as therapeutic agents due to their unique geometry, their propensity to undergo ligand exchanges with biomolecules and their diverse steric and electronic properties. These metal complexes can offer distinct modes of action in living organisms compared to carbon-based molecules. In this study, we investigated the antimicrobial and anti-proliferative abilities of a series of cyclometallated iridium(III) complexes. The iridium(III) complex 1 inhibited the growth of S. aureus with MIC and MBC values of 3.60 and 7.19 1/4M, respectively, indicating its potent bactericidal activity. Moreover, complex 1 also exhibited cytotoxicity against a number of cancer cell lines, with particular potency against ovarian, cervical and melanoma cells. This cyclometallated iridium(III) complex is the first example of a substitutionally-inert, Group 9 organometallic compound utilized as a direct and selective inhibitor of S. aureus.",
author = "Lihua Lu and Liu, {Li Juan} and Chao, {Wei Chieh} and Zhong, {Hai Jing} and Modi Wang and Chen, {Xiu Ping} and Lu, {Jin Jian} and Li, {Ruei Nian} and MA, {Edmond Dik Lung} and Leung, {Chung Hang}",
note = "Funding Information: This work is supported by Hong Kong Baptist University (FRG2/14-15/004), Centre for Cancer and Inflammation Research, School of Chinese Medicine (CCIR-SCM, HKBU), the Health and Medical Research Fund (HMRF/13121482 and HMRF/14130522), the Research Grants Council (HKBU/201811, HKBU/204612, and HKBU/201913), the French National Research Agency/Research Grants Council Joint Research Scheme (A-HKBU201/12-Oligoswitch), Interdisciplinary Research Matching Scheme (RC-IRMS/14-15/06), State Key Laboratory of Environmental and Biological Analysis Research Grant (SKLP-14-15-P001), the Science and Technology Development Fund, Macao SAR (103/2012/A3 and 098/2014/ A2) and the University of Macau (MYRG091(Y3-L2)-ICMS12-LCH, MYRG2015-00137-ICMS-QRCM and MRG023/LCH/2013/ICMS).",
year = "2015",
month = sep,
day = "29",
doi = "10.1038/srep14544",
language = "English",
volume = "5",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
}