@article{f4cb7e1815b64e34ba5f5034e612ae0a,
title = "Identification of an Iridium(III)-Based Inhibitor of Tumor Necrosis Factor-α",
abstract = "The novel iridium(III) complex 1 was verified as a potent inhibitor of the TNF-α-TNFR protein-protein interaction in vitro and in cellulo. The iridium(III) center plays a critical role in organizing the structure of the bioactive metal complex, as the isolated ligands were found to be completely inactive. Both iridium enantiomers inhibited TNF-α-induced NF-κB activity and TNF-α-TNFR binding. 1 represents a promising scaffold for the further development of more potent organometallic TNF-α inhibitors.",
author = "Kang, {Tian Shu} and Zhifeng Mao and Ng, {Chan Tat} and Modi Wang and Wanhe Wang and Chunming Wang and Lee, {Simon Ming Yuen} and Yitao Wang and Leung, {Chung Hang} and Ma, {Dik Lung}",
note = "Funding Information: This work is supported by Hong Kong Baptist University (Grant FRG2/14-15/004 and FRG2/15-16/002), the Health and Medical Research Fund (Grant HMRF/14130522), the Research Grants Council (Grants HKBU/201811, HKBU/204612, and HKBU/201913), the French Agence Nationale de la Recherche/Research Grants Council Joint Research Scheme (AHKBU201/12; Oligoswitch ANR-12-IS07-0001), the National Natural Science Foundation of China (21575121), Guangdong Province Natural Science Foundation (2015A030313816), the Hong Kong Baptist University Century Club Sponsorship Scheme 2015, the Interdisciplinary Research Matching Scheme (RC-IRMS/14-15/06), the Science and Technology Development Fund, Macao SAR (Grant 103/2012/A3), the University of Macau (Grants MYRG091(Y3-L2)-ICMS12-LCH, MYRG2015-00137-ICMS-QRCM, MRG023/LCH/2013/ICMS, and MRG044/LCH/2015/ICMS). Publisher copyright: {\textcopyright} 2016 American Chemical Society",
year = "2016",
month = apr,
day = "28",
doi = "10.1021/acs.jmedchem.6b00112",
language = "English",
volume = "59",
pages = "4026--4031",
journal = "Journal of Medicinal Chemistry",
issn = "0022-2623",
publisher = "American Chemical Society",
number = "8",
}
