Identification of a rhodium(III) complex as a Wee1 inhibitor against: TP53 -mutated triple-negative breast cancer cells

Guan Jun Yang; Hai Jing Zhong; Chung Nga Ko; Suk Yu Wong; Kasipandi Vellaisamy; Min Ye; Edmond Dik Lung Ma; Chung Hang Leung

doi:10.1039/c7cc09384e

Identification of a rhodium(III) complex as a Wee1 inhibitor against: TP53 -mutated triple-negative breast cancer cells

Guan Jun Yang
, Hai Jing Zhong
, Chung Nga Ko
, Suk Yu Wong
, Kasipandi Vellaisamy
, Min Ye
, Edmond Dik Lung Ma^*
, Chung Hang Leung^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

62 Citations (Scopus)

Abstract

The rhodium(iii) complex 1 was identified as a potent Wee1 inhibitor in vitro and in cellulo. It decreased Wee1 activity and unscheduled mitotic entry, and induced cell damage and death in TP53-mutated triple-negative breast cancer cells. 1 represents a promising scaffold for further development of more potent metal-based Wee1 antagonists.

Original language	English
Pages (from-to)	2463-2466
Number of pages	4
Journal	Chemical Communications
Volume	54
Issue number	20
Early online date	16 Jan 2018
DOIs	https://doi.org/10.1039/c7cc09384e
Publication status	Published - 11 Mar 2018

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10.1039/c7cc09384e

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title = "Identification of a rhodium(III) complex as a Wee1 inhibitor against: TP53 -mutated triple-negative breast cancer cells",

abstract = "The rhodium(iii) complex 1 was identified as a potent Wee1 inhibitor in vitro and in cellulo. It decreased Wee1 activity and unscheduled mitotic entry, and induced cell damage and death in TP53-mutated triple-negative breast cancer cells. 1 represents a promising scaffold for further development of more potent metal-based Wee1 antagonists.",

author = "Yang, \{Guan Jun\} and Zhong, \{Hai Jing\} and Ko, \{Chung Nga\} and Wong, \{Suk Yu\} and Kasipandi Vellaisamy and Min Ye and Ma, \{Edmond Dik Lung\} and Leung, \{Chung Hang\}",

note = "Funding Information: This work is supported by Hong Kong Baptist University (FRG2/16-17/007), the Health and Medical Research Fund (HMRF/14130522 and HMRF/14150561), the Research Grants Council (HKBU/12301115 and HKBU/201913), the National Natural Science Foundation of China (21575121), the Guangdong Province Natural Science Foundation (2015A030313816), the Hong Kong Baptist University Century Club Sponsorship Scheme 2017. the Interdisciplinary Research Matching Scheme (RC-IRMS/15-16/03), the Innovation and Technology Fund (ITS/260/16FX), the Collaborative Research Fund (C5026-16G) and the Matching Proof of Concept Fund (MPCF-001-2017/18), the Science and Technology Development Fund, Macao SAR (098/2014/A2), the University of Macau (MYRG2015-00137-ICMS-QRCM and MYRG2016-00151-ICMS-QRCM), and the National Natural Science Foundation of China (21628502).",

year = "2018",

month = mar,

day = "11",

doi = "10.1039/c7cc09384e",

language = "English",

volume = "54",

pages = "2463--2466",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "20",

}

TY - JOUR

T1 - Identification of a rhodium(III) complex as a Wee1 inhibitor against

T2 - TP53 -mutated triple-negative breast cancer cells

AU - Yang, Guan Jun

AU - Zhong, Hai Jing

AU - Ko, Chung Nga

AU - Wong, Suk Yu

AU - Vellaisamy, Kasipandi

AU - Ye, Min

AU - Ma, Edmond Dik Lung

AU - Leung, Chung Hang

N1 - Funding Information: This work is supported by Hong Kong Baptist University (FRG2/16-17/007), the Health and Medical Research Fund (HMRF/14130522 and HMRF/14150561), the Research Grants Council (HKBU/12301115 and HKBU/201913), the National Natural Science Foundation of China (21575121), the Guangdong Province Natural Science Foundation (2015A030313816), the Hong Kong Baptist University Century Club Sponsorship Scheme 2017. the Interdisciplinary Research Matching Scheme (RC-IRMS/15-16/03), the Innovation and Technology Fund (ITS/260/16FX), the Collaborative Research Fund (C5026-16G) and the Matching Proof of Concept Fund (MPCF-001-2017/18), the Science and Technology Development Fund, Macao SAR (098/2014/A2), the University of Macau (MYRG2015-00137-ICMS-QRCM and MYRG2016-00151-ICMS-QRCM), and the National Natural Science Foundation of China (21628502).

PY - 2018/3/11

Y1 - 2018/3/11

N2 - The rhodium(iii) complex 1 was identified as a potent Wee1 inhibitor in vitro and in cellulo. It decreased Wee1 activity and unscheduled mitotic entry, and induced cell damage and death in TP53-mutated triple-negative breast cancer cells. 1 represents a promising scaffold for further development of more potent metal-based Wee1 antagonists.

AB - The rhodium(iii) complex 1 was identified as a potent Wee1 inhibitor in vitro and in cellulo. It decreased Wee1 activity and unscheduled mitotic entry, and induced cell damage and death in TP53-mutated triple-negative breast cancer cells. 1 represents a promising scaffold for further development of more potent metal-based Wee1 antagonists.

UR - https://www.scopus.com/pages/publications/85043327223

U2 - 10.1039/c7cc09384e

DO - 10.1039/c7cc09384e

M3 - Journal article

C2 - 29367998

AN - SCOPUS:85043327223

SN - 1359-7345

VL - 54

SP - 2463

EP - 2466

JO - Chemical Communications

JF - Chemical Communications

IS - 20

ER -

Identification of a rhodium(III) complex as a Wee1 inhibitor against: TP53 -mutated triple-negative breast cancer cells

Abstract

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