Identification of a rhodium(III) complex as a Wee1 inhibitor against: TP53 -mutated triple-negative breast cancer cells

Guan Jun Yang, Hai Jing Zhong, Chung Nga Ko, Suk Yu Wong, Kasipandi Vellaisamy, Min Ye, Edmond Dik Lung MA*, Chung Hang Leung

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

The rhodium(iii) complex 1 was identified as a potent Wee1 inhibitor in vitro and in cellulo. It decreased Wee1 activity and unscheduled mitotic entry, and induced cell damage and death in TP53-mutated triple-negative breast cancer cells. 1 represents a promising scaffold for further development of more potent metal-based Wee1 antagonists.

Original languageEnglish
Pages (from-to)2463-2466
Number of pages4
JournalChemical Communications
Volume54
Issue number20
DOIs
Publication statusPublished - 2018

Scopus Subject Areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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