@article{bfd9688557d94dfd8cc1fda71ca14287,
title = "Identification of a rhodium(III) complex as a Wee1 inhibitor against: TP53 -mutated triple-negative breast cancer cells",
abstract = "The rhodium(iii) complex 1 was identified as a potent Wee1 inhibitor in vitro and in cellulo. It decreased Wee1 activity and unscheduled mitotic entry, and induced cell damage and death in TP53-mutated triple-negative breast cancer cells. 1 represents a promising scaffold for further development of more potent metal-based Wee1 antagonists.",
author = "Yang, {Guan Jun} and Zhong, {Hai Jing} and Ko, {Chung Nga} and Wong, {Suk Yu} and Kasipandi Vellaisamy and Min Ye and Ma, {Edmond Dik Lung} and Leung, {Chung Hang}",
note = "Funding Information: This work is supported by Hong Kong Baptist University (FRG2/16-17/007), the Health and Medical Research Fund (HMRF/14130522 and HMRF/14150561), the Research Grants Council (HKBU/12301115 and HKBU/201913), the National Natural Science Foundation of China (21575121), the Guangdong Province Natural Science Foundation (2015A030313816), the Hong Kong Baptist University Century Club Sponsorship Scheme 2017. the Interdisciplinary Research Matching Scheme (RC-IRMS/15-16/03), the Innovation and Technology Fund (ITS/260/16FX), the Collaborative Research Fund (C5026-16G) and the Matching Proof of Concept Fund (MPCF-001-2017/18), the Science and Technology Development Fund, Macao SAR (098/2014/A2), the University of Macau (MYRG2015-00137-ICMS-QRCM and MYRG2016-00151-ICMS-QRCM), and the National Natural Science Foundation of China (21628502).",
year = "2018",
month = mar,
day = "11",
doi = "10.1039/c7cc09384e",
language = "English",
volume = "54",
pages = "2463--2466",
journal = "Chemical Communications",
issn = "1359-7345",
publisher = "Royal Society of Chemistry",
number = "20",
}