TY - JOUR
T1 - Hydroxylated polybrominated diphenyl ethers (OH-PBDEs) in paired maternal and neonatal samples from South China
T2 - Placental transfer and potential risks
AU - Chen, Zhuo Jia
AU - Liu, Han Yan
AU - Ho, Ka Lok
AU - Huang, Hong Bin
AU - Liu, Qing
AU - Man, Yu Bon
AU - Lam, Michael Hon Wah
AU - Du, Jun
AU - Wong, Ming Hung
AU - Wang, Hong Sheng
N1 - Funding Information:
This research was supported by the National Natural Science Foundation of China (Grant no. 81302317 and no. 81472470 ), the Seed Collaborative Research Fund from the State Key Laboratory in Marine Pollution ( SCRF0003 ), the Guangdong Natural Science Funds for Distinguished Young Scholar (No. 2014A030306025 ), the Pearl River S&T Nova Program of Guangzhou (No. 201506010039 ), the Fundamental Research Funds for the Central Universities (Sun Yat-sen University) (No. 12ykpy09 ), the Science and Technology Planning Project of Guangdong Province, China (No. 2012B031500005 ), and the Opening Project Program of State Key Laboratory of Oncology in South China (No. HN2014-09 ).
PY - 2016/7/1
Y1 - 2016/7/1
N2 - Hydroxylated polybrominated diphenyl ethers (OH-PBDEs) are attracting more and more attention for the neurodevelopment toxicity effects. We evaluated the concentrations of 15 individual OH-PBDEs and 3 bromophenol (BRP) congeners in 30 mother-newborn paired placenta, breast milk, fetal cord blood, and neonatal urine samples collected from South China. The geometric mean (GM) concentrations of ∑OH-PBDEs were 37.6, 61.3, and 76.8 pg g-1 ww in placenta, breast milk, and cord blood, respectively. The GM concentrations of ∑BRPs were 47.6, 119, and 30.2 pg g-1 ww in placenta, breast milk, and cord blood, respectively. The GM concentrations of ∑OH-PBDEs and ∑BRPs in neonatal urine were 72.0 and 79.8 pg ml-1, respectively. Of the 15 OH-PBDE congeners analyzed, the three most frequently detected congeners were 2'-OH-BDE-68 (72.1%), 6-OH-BDE-47 (67.6%), and 2'-OH-BDE-28 (65.8%). The estimated daily intake (EDI) of OH-PBDEs for the breast-fed infants was 9.31±4.00 ng kg-1 bw day. The accumulation of OH-PBDEs in newborns was much lower than the estimated lowest observed-effect concentration (LOEC) of neurotoxicity. The present study provided the first systematic fundamental data that exposure to OH-PBDEs for newborn and their mothers in South China.
AB - Hydroxylated polybrominated diphenyl ethers (OH-PBDEs) are attracting more and more attention for the neurodevelopment toxicity effects. We evaluated the concentrations of 15 individual OH-PBDEs and 3 bromophenol (BRP) congeners in 30 mother-newborn paired placenta, breast milk, fetal cord blood, and neonatal urine samples collected from South China. The geometric mean (GM) concentrations of ∑OH-PBDEs were 37.6, 61.3, and 76.8 pg g-1 ww in placenta, breast milk, and cord blood, respectively. The GM concentrations of ∑BRPs were 47.6, 119, and 30.2 pg g-1 ww in placenta, breast milk, and cord blood, respectively. The GM concentrations of ∑OH-PBDEs and ∑BRPs in neonatal urine were 72.0 and 79.8 pg ml-1, respectively. Of the 15 OH-PBDE congeners analyzed, the three most frequently detected congeners were 2'-OH-BDE-68 (72.1%), 6-OH-BDE-47 (67.6%), and 2'-OH-BDE-28 (65.8%). The estimated daily intake (EDI) of OH-PBDEs for the breast-fed infants was 9.31±4.00 ng kg-1 bw day. The accumulation of OH-PBDEs in newborns was much lower than the estimated lowest observed-effect concentration (LOEC) of neurotoxicity. The present study provided the first systematic fundamental data that exposure to OH-PBDEs for newborn and their mothers in South China.
KW - Body accumulation
KW - Human tissues
KW - Newborns
KW - OH-PBDEs
KW - Paired samples
UR - https://www.scopus.com/pages/publications/84961726976
U2 - 10.1016/j.envres.2016.03.021
DO - 10.1016/j.envres.2016.03.021
M3 - Journal article
C2 - 27035923
AN - SCOPUS:84961726976
SN - 0013-9351
VL - 148
SP - 72
EP - 78
JO - Environmental Research
JF - Environmental Research
ER -