Hydroxylated polybrominated diphenyl ethers (OH-PBDEs) in paired maternal and neonatal samples from South China: Placental transfer and potential risks

Zhuo Jia Chen, Han Yan Liu, Ka Lok Ho, Hong Bin Huang, Qing Liu, Yu Bon Man, Michael Hon Wah Lam, Jun Du, Ming Hung WONG*, Hong Sheng Wang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Hydroxylated polybrominated diphenyl ethers (OH-PBDEs) are attracting more and more attention for the neurodevelopment toxicity effects. We evaluated the concentrations of 15 individual OH-PBDEs and 3 bromophenol (BRP) congeners in 30 mother-newborn paired placenta, breast milk, fetal cord blood, and neonatal urine samples collected from South China. The geometric mean (GM) concentrations of ∑OH-PBDEs were 37.6, 61.3, and 76.8 pg g-1 ww in placenta, breast milk, and cord blood, respectively. The GM concentrations of ∑BRPs were 47.6, 119, and 30.2 pg g-1 ww in placenta, breast milk, and cord blood, respectively. The GM concentrations of ∑OH-PBDEs and ∑BRPs in neonatal urine were 72.0 and 79.8 pg ml-1, respectively. Of the 15 OH-PBDE congeners analyzed, the three most frequently detected congeners were 2'-OH-BDE-68 (72.1%), 6-OH-BDE-47 (67.6%), and 2'-OH-BDE-28 (65.8%). The estimated daily intake (EDI) of OH-PBDEs for the breast-fed infants was 9.31±4.00 ng kg-1 bw day. The accumulation of OH-PBDEs in newborns was much lower than the estimated lowest observed-effect concentration (LOEC) of neurotoxicity. The present study provided the first systematic fundamental data that exposure to OH-PBDEs for newborn and their mothers in South China.

Original languageEnglish
Pages (from-to)72-78
Number of pages7
JournalEnvironmental Research
Volume148
DOIs
Publication statusPublished - 1 Jul 2016

Scopus Subject Areas

  • Biochemistry
  • Environmental Science(all)

User-Defined Keywords

  • Body accumulation
  • Human tissues
  • Newborns
  • OH-PBDEs
  • Paired samples

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