TY - JOUR
T1 - Hydroxylated and methoxylated polybrominated diphenyl ethers in blood plasma of humans in Hong Kong
AU - Wang, Hong Sheng
AU - Chen, Zhuo Jia
AU - Ho, Ka Lok
AU - Ge, Li Chen
AU - Du, Jun
AU - Lam, Michael Hon Wah
AU - Giesy, John P.
AU - Wong, Ming Hung
AU - Wong, Chris Kong Chu
N1 - Funding Information:
This research was supported by the National Natural Science Foundation of China (grant no. 31101071 ), the National Basic Research Program of China ( 973 Program, no. 2011CB9358003 ), and the Research Grants Council of the University Grants Committee of Hong Kong (Collaborative Research Fund, HKBU1/CRF/08 and Special Equipment Grant, HKBU09 ). The research was supported, in part, by a Discovery Grant from the Natural Science and Engineering Research Council of Canada ( Project # 326415–07 ). Prof. Giesy was supported by the Canada Research Chair program , an at large Chair Professorship at the Department of Biology and Chemistry and State Key Laboratory in Marine Pollution, City University of Hong Kong, The Einstein Professor Program of the Chinese Academy of Sciences and the Visiting Professor Program of King Saud University .
PY - 2012/10/15
Y1 - 2012/10/15
N2 - Hydroxylated (OH-) and methoxylated (MeO-) polybrominated diphenyl ethers (PBDE) are suspected endocrine disruptors. Little is known about the accumulation or sources of these chemicals in tissues of humans, particularly those residing in Hong Kong, which is one of the most densely populated cities in the world. Seven MeO-BDEs, fifteen OH-BDEs and three bromophenols (BRPs) were analyzed in blood plasma of 116 humans that had been collected by the Hong Kong Red Cross. Total concentrations of MeO-BDEs, OH-BDEs and BRPs ranged from 3.8×102 to 52×103pgg-1 lipid (median 4.5×103pgg-1), 5.3 to 4.9×102pgg-1 lipid (81pgg-1) and ND to 1.1×102pgg-1 lipid (3.7pgg-1), respectively. 3-MeO-BDE-47, 6-OH-BDE-47 and 2, 4, 5-TBP were the predominant MeO-BDEs, OH-BDEs and BRPs, respectively. These results are consistent with accumulation of MeO-BDEs, OH-BDEs and BRPs in human plasma being primarily from natural products and inter-conversion of natural products. Coefficients of determination for some pairs of congeners such as 3-OH-BDE-100 and 6-OH-BDE-47, 6-OH-BDE-85 and 5'-OH-BDE-99, and 2, 4-DBP and 6-OH-BDE-85, were near 1.0, which is consistent with them having common sources. Patterns of relative concentrations of the target analytes were similar in the diet, particularly fish, as in blood plasma of humans, which suggests that the diet and particularly seafood might be a source of these compounds and PBDEs. Furthermore, biotransformation of natural chemicals such as OH-BDEs to BRPs might be the primary route of their elimination from humans.
AB - Hydroxylated (OH-) and methoxylated (MeO-) polybrominated diphenyl ethers (PBDE) are suspected endocrine disruptors. Little is known about the accumulation or sources of these chemicals in tissues of humans, particularly those residing in Hong Kong, which is one of the most densely populated cities in the world. Seven MeO-BDEs, fifteen OH-BDEs and three bromophenols (BRPs) were analyzed in blood plasma of 116 humans that had been collected by the Hong Kong Red Cross. Total concentrations of MeO-BDEs, OH-BDEs and BRPs ranged from 3.8×102 to 52×103pgg-1 lipid (median 4.5×103pgg-1), 5.3 to 4.9×102pgg-1 lipid (81pgg-1) and ND to 1.1×102pgg-1 lipid (3.7pgg-1), respectively. 3-MeO-BDE-47, 6-OH-BDE-47 and 2, 4, 5-TBP were the predominant MeO-BDEs, OH-BDEs and BRPs, respectively. These results are consistent with accumulation of MeO-BDEs, OH-BDEs and BRPs in human plasma being primarily from natural products and inter-conversion of natural products. Coefficients of determination for some pairs of congeners such as 3-OH-BDE-100 and 6-OH-BDE-47, 6-OH-BDE-85 and 5'-OH-BDE-99, and 2, 4-DBP and 6-OH-BDE-85, were near 1.0, which is consistent with them having common sources. Patterns of relative concentrations of the target analytes were similar in the diet, particularly fish, as in blood plasma of humans, which suggests that the diet and particularly seafood might be a source of these compounds and PBDEs. Furthermore, biotransformation of natural chemicals such as OH-BDEs to BRPs might be the primary route of their elimination from humans.
KW - Asia
KW - Bromophenols
KW - Diet
KW - Natural products
KW - PBDE
KW - Sources
UR - http://www.scopus.com/inward/record.url?scp=84863451654&partnerID=8YFLogxK
U2 - 10.1016/j.envint.2012.06.004
DO - 10.1016/j.envint.2012.06.004
M3 - Journal article
C2 - 22771521
AN - SCOPUS:84863451654
SN - 0160-4120
VL - 47
SP - 66
EP - 72
JO - Environment International
JF - Environment International
ER -