Human placental transfer of perfluoroalkyl acid precursors: Levels and profiles in paired maternal and cord serum

Lin Yang, Zhen Wang, Yu Shi, Jingguang Li*, Yuxin Wang, Yunfeng Zhao, Yongning Wu, Zongwei CAI

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

46 Citations (Scopus)


Perfluoroalkyl acids (PFAAs) precursors, the indirect source of PFAA exposure, have been observed in environmental and human samples. However, the maternal-fetal transfer of these chemicals has not been well examined. In this study, 50 paired maternal and cord serum samples collected in Jiangsu province of China were analyzed for fifteen PFAA precursors. Among the detected PFAAs, 6:2 fluorotelomer sulfonate (6:2 FTS), N-methyl- and N-ethyl-perfluorooctanesulfonamidoacetates had comparable detection rate in both maternal and cord sera, while the mean concentrations and detection rates of 8:2 FTS and perfluorooctane sulfonamide (PFOSA) were higher in maternal sera compared to cord sera (Mann-Whitney U test, P < 0.05). Analysis of variance and least significant difference tests showed that the youngest maternal age group (21-24 years old) had the highest concentration of 6:2 FTS in cord sera. Maternal serum PFOSA was found significantly correlated with the cord serum perfluorooctanesulfonate (PFOS) (Spearman test, r = 0.361, P = 0.010), indicating that maternal serum PFOSA might be an indirect source of PFOS in fetuses. The obtained results suggested the potential prenatal exposure and human placental transfer of perfluoroalkyl acid precursors.

Original languageEnglish
Pages (from-to)1631-1638
Number of pages8
Publication statusPublished - 1 Feb 2016

Scopus Subject Areas

  • Environmental Engineering
  • Environmental Chemistry
  • Chemistry(all)
  • Pollution
  • Health, Toxicology and Mutagenesis

User-Defined Keywords

  • Perfluoroalkyl acids
  • Placenta transfer
  • Precursors
  • Prenatal exposure
  • Serum analysis


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