TY - JOUR
T1 - Human placental transfer of perfluoroalkyl acid precursors
T2 - Levels and profiles in paired maternal and cord serum
AU - Yang, Lin
AU - Wang, Zhen
AU - Shi, Yu
AU - Li, Jingguang
AU - Wang, Yuxin
AU - Zhao, Yunfeng
AU - Wu, Yongning
AU - CAI, Zongwei
N1 - Funding Information:
We thank all the mothers who collaborated with the study and donated serum samples. We appreciate the comment and discussion from Jiaying Liu from University of Alberta. Lin Yang and Zhen Wang contributed equally to this article. This research was funded by the National Nature Science of Foundation of China ( 21407033 ).
PY - 2016/2/1
Y1 - 2016/2/1
N2 - Perfluoroalkyl acids (PFAAs) precursors, the indirect source of PFAA exposure, have been observed in environmental and human samples. However, the maternal-fetal transfer of these chemicals has not been well examined. In this study, 50 paired maternal and cord serum samples collected in Jiangsu province of China were analyzed for fifteen PFAA precursors. Among the detected PFAAs, 6:2 fluorotelomer sulfonate (6:2 FTS), N-methyl- and N-ethyl-perfluorooctanesulfonamidoacetates had comparable detection rate in both maternal and cord sera, while the mean concentrations and detection rates of 8:2 FTS and perfluorooctane sulfonamide (PFOSA) were higher in maternal sera compared to cord sera (Mann-Whitney U test, P < 0.05). Analysis of variance and least significant difference tests showed that the youngest maternal age group (21-24 years old) had the highest concentration of 6:2 FTS in cord sera. Maternal serum PFOSA was found significantly correlated with the cord serum perfluorooctanesulfonate (PFOS) (Spearman test, r = 0.361, P = 0.010), indicating that maternal serum PFOSA might be an indirect source of PFOS in fetuses. The obtained results suggested the potential prenatal exposure and human placental transfer of perfluoroalkyl acid precursors.
AB - Perfluoroalkyl acids (PFAAs) precursors, the indirect source of PFAA exposure, have been observed in environmental and human samples. However, the maternal-fetal transfer of these chemicals has not been well examined. In this study, 50 paired maternal and cord serum samples collected in Jiangsu province of China were analyzed for fifteen PFAA precursors. Among the detected PFAAs, 6:2 fluorotelomer sulfonate (6:2 FTS), N-methyl- and N-ethyl-perfluorooctanesulfonamidoacetates had comparable detection rate in both maternal and cord sera, while the mean concentrations and detection rates of 8:2 FTS and perfluorooctane sulfonamide (PFOSA) were higher in maternal sera compared to cord sera (Mann-Whitney U test, P < 0.05). Analysis of variance and least significant difference tests showed that the youngest maternal age group (21-24 years old) had the highest concentration of 6:2 FTS in cord sera. Maternal serum PFOSA was found significantly correlated with the cord serum perfluorooctanesulfonate (PFOS) (Spearman test, r = 0.361, P = 0.010), indicating that maternal serum PFOSA might be an indirect source of PFOS in fetuses. The obtained results suggested the potential prenatal exposure and human placental transfer of perfluoroalkyl acid precursors.
KW - Perfluoroalkyl acids
KW - Placenta transfer
KW - Precursors
KW - Prenatal exposure
KW - Serum analysis
UR - http://www.scopus.com/inward/record.url?scp=84953791618&partnerID=8YFLogxK
U2 - 10.1016/j.chemosphere.2015.10.063
DO - 10.1016/j.chemosphere.2015.10.063
M3 - Journal article
C2 - 26517392
AN - SCOPUS:84953791618
SN - 0045-6535
VL - 144
SP - 1631
EP - 1638
JO - Chemosphere
JF - Chemosphere
ER -