Human cytomegalovirus latent infection and associated viral gene expression

Barry Slobedman*, John Z Cao, Selmir Avdic, Bradley Webster, Samantha McAllery, Allen KL Cheung, Joanne CG Tan, Allison Abendroth

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

45 Citations (Scopus)


Human cytomegalovirus (HCMV) is a clinically important and ubiquitous herpesvirus. Following primary productive infection the virus is not completely eliminated from the host, but instead establishes a lifelong latent infection without detectable virus production, from where it can reactivate at a later stage to generate new infectious virus. Reactivated HCMV often results in life-threatening disease in immunocompromised individuals, particularly allogeneic stem cell and solid organ transplant recipients, where it remains one of the most difficult opportunistic pathogens that complicate the care of these patients. The ability of HCMV to establish and reactivate from latency is central to its success as a human pathogen, yet latency remains very poorly understood. This article will cover several aspects of HCMV latency, with a focus on current understanding of viral gene expression and functions during this phase of infection.

Original languageEnglish
Pages (from-to)883-900
Number of pages18
JournalFuture Microbiology
Issue number6
Publication statusPublished - Jun 2010

Scopus Subject Areas

  • Microbiology
  • Microbiology (medical)

User-Defined Keywords

  • Herpes
  • Human cytomegalovirus
  • Latent infection
  • Myeloid cells
  • Reactivation
  • Viral gene expression


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