Hit Identification of Anthraquinone Based Molecules as c-myc G-Quadruplex Inducers/Stabilizers via in silico Structural Similarity Approach

Victor Pui-Yan Ma, Wan-Chi Lam, Dik Lung Ma, Chung-Hang Leung

Research output: Contribution to journalArticle

Abstract

Natural products in Traditional Chinese Medicine (TCM) such as anthraquinone derivatives have a wide variety of pharmacological properties as well as proven record of high efficacy. Previously, our group reported an anthraquinone derivative Fonsecin B as c-myc G-quadruplex stabilizer. We herein report two bioactive anthraquinones with modifiable hydroxyl groups abundant in Chinese Medicine Rheum Palmatum L. (also known as Da Huang) as c-myc G-quadruplex stabilizer, identified by in silico structural similarity approach. Interaction of the anthraquinones with c-myc G-quadruplex was investigated by PCR Stop Assay
Original languageEnglish
Pages (from-to)108-111
Number of pages4
JournalInternational Review of Biophysical Chemistry
Volume2
Issue number4
Publication statusPublished - Aug 2011

User-Defined Keywords

  • Anthraquinones
  • c-myc
  • G-quadruplex
  • Traditional Chinese Medicine
  • Computer-aided Drug Discovery

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