Highly enantioselective access to chiral chromanes and thiochromanes via Cu-catalyzed hydroamination with anthranils

Xiaodong Gu, Ling Meng, Mingliang Li, Jun (Joelle) Wang

Research output: Contribution to journalArticlepeer-review

Abstract

A Cu(I)/(R,R)-Ph-BPE-catalyzed enantioselective hydroamination of 2H-chromenes and 2H-thiochromenes with anthranils is developed, which enables highly efficient and atom-economical asymmetric access to a series of 4-arylamino chromanes and thiochromanes bearing a benzylic alcohol functionality in high yields (up to 96%) with excellent enantioselectivities (up to 99% ee). These valuable chiral chromane and thiochromane products may act as key intermediates to access nitrogen-, oxygen- and sulfur-containing bioactive compounds with more molecular complexity.
Original languageEnglish
Pages (from-to)1563-1568
Number of pages6
JournalOrganic Chemistry Frontiers
Volume8
Issue number7
DOIs
Publication statusPublished - 7 Apr 2021

Scopus Subject Areas

  • Organic Chemistry

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