Highly efficient Pd/tetraphosphine catalytic system for copper-free sonogashira reactions of aryl bromides with terminal alkynes

Tao YI, Min Mo, Hai Yan Fu, Rui Xiang Li*, Hua Chen, Xian Jun Li

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

In this study, an easily synthesized polydentate ligand N,N,N',N'-tetra(diphenylphosphinomethyl)-1,2-ethylenediamine (1) in combination with [Pd(C 3H 5)Cl] 2 was found to be an active catalyst in copper-free Sonogashira reactions. Most substrates, including steric hindered phenyl bromides and heteroaryl bromides, could couple efficiently with terminal alkynes in the presence of low catalyst loading (0.1 mol%) and this catalytic system showed excellent functional group tolerance. The influence of water in this system was also preliminarily investigated via 31P NMR in situ; that is, appropriate water favors the reaction while excess hindered this reaction.

Original languageEnglish
Pages (from-to)594-600
Number of pages7
JournalCatalysis Letters
Volume142
Issue number5
DOIs
Publication statusPublished - May 2012

Scopus Subject Areas

  • Catalysis
  • Chemistry(all)

User-Defined Keywords

  • Aryl bromides
  • Copper-free
  • Palladium
  • Sonogashira reaction
  • Tetraphosphine

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