Abstract
A method that accurately indicates the end-point of precipitation reactions by the measurement of the relative intensity of the scattered light in the titrate is presented. A new nephelometric titrator with an internal nephelometric sensor has been devised. The work of the titrator including the sensor and change in the turbidity of the titrate and intensity of the scattered light are described. The accuracy of the nephelometric titrimetry is discussed theoretically. The titration of NaCl with AgNO3 serves as a model. A relative error as well as deviation is within 0.2% under the experimental conditions. The applicability of the titrimetry in pharmaceutical analyses, for example, phenytoin sodium and procaine hydrochloride, is generally illustrated.
Original language | English |
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Pages (from-to) | 441-448 |
Number of pages | 8 |
Journal | Journal of Pharmaceutical Sciences |
Volume | 93 |
Issue number | 2 |
DOIs | |
Publication status | Published - Feb 2004 |
Scopus Subject Areas
- Pharmaceutical Science
User-Defined Keywords
- Highly accurate nephelometric titrimetry
- Internal nephelometric sensor
- Phenytoin sodium
- Procaine hydrochloride
- Solubility product constant