Highly Accurate Nephelometric Titrimetry

Xiancheng Zhan, Chengrong Li*, Zhiyi Li, Xiucen Yang, Shuguang Zhong, Tao YI

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

A method that accurately indicates the end-point of precipitation reactions by the measurement of the relative intensity of the scattered light in the titrate is presented. A new nephelometric titrator with an internal nephelometric sensor has been devised. The work of the titrator including the sensor and change in the turbidity of the titrate and intensity of the scattered light are described. The accuracy of the nephelometric titrimetry is discussed theoretically. The titration of NaCl with AgNO3 serves as a model. A relative error as well as deviation is within 0.2% under the experimental conditions. The applicability of the titrimetry in pharmaceutical analyses, for example, phenytoin sodium and procaine hydrochloride, is generally illustrated.

Original languageEnglish
Pages (from-to)441-448
Number of pages8
JournalJournal of Pharmaceutical Sciences
Volume93
Issue number2
DOIs
Publication statusPublished - Feb 2004

Scopus Subject Areas

  • Pharmaceutical Science

User-Defined Keywords

  • Highly accurate nephelometric titrimetry
  • Internal nephelometric sensor
  • Phenytoin sodium
  • Procaine hydrochloride
  • Solubility product constant

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