TY - JOUR
T1 - Higher-generation type III-B rotaxane dendrimers with controlling particle size in three-dimensional molecular switching
AU - Kwan, Chak Shing
AU - Zhao, Rundong
AU - VAN HOVE, M. A.
AU - CAI, Zongwei
AU - LEUNG, Ken C F
N1 - Funding Information:
This study was supported by the Area of Excellence Scheme (AoE-P03/08) from the University Grants Committee of Hong Kong. This work was partly supported by the Collaborative Research Fund of Hong Kong Research Grants Council (Project No. C2014-15G) and the Inter-institutional Collaborative Research Scheme, a grant sponsored by the Research Committee of HKBU (RC-ICRS/15-16/01). We also acknowledge the computing resources of the Tianhe2-JK cluster at the Beijing Computational Science Research Center and of the Tianhe2 cluster at the National Supercomputer Center in Guangzhou, China. ICTS is supported by the Institute of Creativity of HKBU, which is sponsored by the Hung Hin Shiu Charitable Foundation.
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Type III-B rotaxane dendrimers (T3B-RDs) are hyperbranched macromolecules with mechanical bonds on every branching unit. Here we demonstrate the design, synthesis, and characterization of first to third (G1-G3), and up to the fourth (G4) generation (MW > 22,000 Da) of pure organic T3B-RDs and dendrons through the copper-catalyzed alkyne-azide cycloaddition (CuAAC) reaction. By utilizing multiple molecular shuttling of the mechanical bonds within the sphere-like macromolecule, a collective three-dimensional contract-extend molecular motion is demonstrated by diffusion ordered spectroscopy (DOSY) and atomic force microscopy (AFM). The discrete T3B-RDs are further observed and characterized by AFM, dynamic light scattering (DLS), and mass spectrometry (MS). The binding of chlorambucil and pH-triggered switching of the T3B-RDs are also characterized by 1H-NMR spectroscopy.
AB - Type III-B rotaxane dendrimers (T3B-RDs) are hyperbranched macromolecules with mechanical bonds on every branching unit. Here we demonstrate the design, synthesis, and characterization of first to third (G1-G3), and up to the fourth (G4) generation (MW > 22,000 Da) of pure organic T3B-RDs and dendrons through the copper-catalyzed alkyne-azide cycloaddition (CuAAC) reaction. By utilizing multiple molecular shuttling of the mechanical bonds within the sphere-like macromolecule, a collective three-dimensional contract-extend molecular motion is demonstrated by diffusion ordered spectroscopy (DOSY) and atomic force microscopy (AFM). The discrete T3B-RDs are further observed and characterized by AFM, dynamic light scattering (DLS), and mass spectrometry (MS). The binding of chlorambucil and pH-triggered switching of the T3B-RDs are also characterized by 1H-NMR spectroscopy.
UR - http://www.scopus.com/inward/record.url?scp=85041683598&partnerID=8YFLogxK
U2 - 10.1038/s41467-018-02902-z
DO - 10.1038/s41467-018-02902-z
M3 - Journal article
C2 - 29402942
AN - SCOPUS:85041683598
SN - 2041-1723
VL - 9
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 497
ER -