High-sensitivity cardiac troponin T release after a single bout of high-intensity interval exercise in experienced marathon runners

Feifei Li, Longyan Yi, Huiping Yan, Xuejing Wang, Jinlei Nie, Haifeng Zhang, Frank H K FU, Yanpeng Zang, Shuo Yang, Yifan Lu*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

13 Citations (Scopus)


Objective The purpose of this study was to investigate the effects of a single bout of high-intensity interval exercise (HIIE) on high-sensitivity cardiac troponin T (hs-cTnT) release and to explore the potential influencing factors. Methods Twenty-one experienced marathon runners completed HIIE on treadmill. Each bout of HIIE included a hard run (15.8 ± 1.3 km·h−1) at 90% vVO2max for 2 min followed by an easy run (8.8 ± 0.7 km·h−1) at 50% vVO2max for 2 min performed 23 times within 92 min. Heart rate (HR) was recorded every 2 min during HIIE. The hs-cTnT level was measured before (pre), immediately after (0 h), and at 4 and 24 h after exercise. Results The hs-cTnT level was elevated at 0 h, peaked at 4 h, and had not returned to the baseline value at 24 h after exercise. The response of hs-cTnT at 4 h was positively related to exercise HR. Subjects with a greater increase in hs-cTnT level had a higher exercise HR under fixed exercise intensity. Conclusion HIIE at 90% vVO2max interspersed with 50% vVO2max for recovery can elicit hs-cTnT elevation. HR is a good predictor of exercise-induced cardiac troponin (cTn) release under fixed exercise intensity. Further study should consider to correct for HR when constructing impact factors contributing to exercise-induced cTn release.

Original languageEnglish
Pages (from-to)49-54
Number of pages6
JournalJournal of Exercise Science and Fitness
Issue number2
Publication statusPublished - Dec 2017

Scopus Subject Areas

  • Physical Therapy, Sports Therapy and Rehabilitation
  • Public Health, Environmental and Occupational Health

User-Defined Keywords

  • Exercise intensity
  • Exercise-induced cardiac troponin release
  • Heart rate
  • High-intensity interval exercise
  • High-sensitivity cardiac troponin T
  • Marathon


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