Hierarchically porous zirconium-based metal–organic frameworks for rapid adsorption and enrichment of sulfonamide antibiotics

Lizhen Han, Peige Qin, Mengyuan Li, Dan Li, Mengyao Mu, Yanmei Gao, Shiping Zhu, Minghua Lu*, Zongwei Cai

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

28 Citations (Scopus)


Due to serious risk to human health and eco-environmental security, antibiotics in water and foods received considerable concern. Herein, a series of stable hierarchically porous zirconium-based metal–organic frameworks (MOFs) namely HP-NU-902-X were prepared via modulator-induced defect-guided formation strategy for the first time and functioned as sorbents to removal and preconcentration of sulfonamide antibiotics (SAs). The pore size and specific surface area of HP-NU-902-X were systematically adjusted by changing concentration of monocarboxylic acid modulator. The adsorption performance of HP-NU-902-X were greatly improved by forming defects. Experiments demonstrated that HP-NU-902-80 possessed the highest adsorption efficiency to SAs. The limits of detection (S/N = 3) were achieved ranging 0.08 to 0.25 ng/mL. The spiked recoveries of water and milk samples were obtained in the range of 70.34–103.4 % and 73.83–100.5 %. Enrichment factors were calculated between 203 and 358. The SAs can be completely removed within 10 min, and adsorption kinetic data was best consistent with pseudo-second-order model. Using Langmuir isotherm model, maximum adsorption capacities for sulfadiazine, sulfapyridine, sulfametoxydiazine, sulfachloropyridazine, sulfabenzamide and sulfamethazine were calculated as 279.9, 467.7, 414.4, 433.1, 415.5 and 336.6 mg/g, respectively. The improved adsorption capacity was mainly owing to high surface area and extra defect sites. This synthetic strategy provides a way to prepare stable defective MOFs and enhance their potential applications in removal and extraction of environmental pollutants.

Original languageEnglish
Article number140969
JournalChemical Engineering Journal
Early online date14 Dec 2022
Publication statusPublished - 15 Jan 2023

Scopus Subject Areas

  • Chemistry(all)
  • Environmental Chemistry
  • Chemical Engineering(all)
  • Industrial and Manufacturing Engineering

User-Defined Keywords

  • Adsorption
  • Dispersive solid-phase extraction
  • HP-NU-902
  • Metal–organic frameworks
  • Sample pretreatment
  • Sulfonamide antibiotics


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