Hierarchical Connectome Modes and Critical State Jointly Maximize Human Brain Functional Diversity

Rong Wang, Pan Lin, Mianxin Liu, Ying Wu, Tao Zhou, Changsong ZHOU

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

The brain requires diverse segregated and integrated processing to perform normal functions in terms of anatomical structure and self-organized dynamics with critical features, but the fundamental relationships between the complex structural connectome, critical state, and functional diversity remain unknown. Herein, we extend the eigenmode analysis to investigate the joint contribution of hierarchical modular structural organization and critical state to brain functional diversity. We show that the structural modes inherent to the hierarchical modular structural connectome allow a nested functional segregation and integration across multiple spatiotemporal scales. The real brain hierarchical modular organization provides large structural capacity for diverse functional interactions, which are generated by sequentially activating and recruiting the hierarchical connectome modes, and the critical state can best explore the capacity to maximize the functional diversity. Our results reveal structural and dynamical mechanisms that jointly support a balanced segregated and integrated brain processing with diverse functional interactions, and they also shed light on dysfunctional segregation and integration in neurodegenerative diseases and neuropsychiatric disorders.

Original languageEnglish
Article number038301
JournalPhysical Review Letters
Volume123
Issue number3
DOIs
Publication statusPublished - 15 Jul 2019

Scopus Subject Areas

  • Physics and Astronomy(all)

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