Herbal isoprenols induce apoptosis in human colon cancer cells through transcriptional activation of PPARγ

Kathy K W AU YEUNG, Po Ling Liu, Cecilia Chan, Wing Yee Wu, Susanna Sau Tuen Lee, Joshua KO

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

Farnesol (FOH) and geranylgeraniol (GGOH) possess anti-tumor potential, while peroxisome proliferator-activated receptor γ (PPARγ) has exhibited modulating effects in colorectal cancers. We investigated the anti-carcinogenic effects of these isoprenols in HT-29 and HCT116 colon cancer cells and PPARγ involvement. Results indicate that the FOH- and GGOH-induced apoptosis involve caspase 3 activation, PARP cleavage, nuclear chromatin condensation, down-regulation of Bcl-xL and survivin expression, with increased PPARγ promoter activity. Pretreatment of the PPARγ antagonist GW9662 reduces FOH-induced growth inhibition and the associated PARP cleavage. We conclude that PPARγ activation is essential to elicit the anti-carcinogenic action of herbal isoprenols in colonic cancer cells.

Original languageEnglish
Pages (from-to)708-717
Number of pages10
JournalCancer Investigation
Volume26
Issue number7
DOIs
Publication statusPublished - Aug 2008

Scopus Subject Areas

  • Oncology
  • Cancer Research

User-Defined Keywords

  • FOH
  • GGOH
  • GW9662
  • HCT116 cells
  • HT-29 cells
  • PPARγ

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