Henrin A: A new anti-HIV Ent-kaurane diterpene from Pteris henryi

  • Wan Fei Li
  • , Juan Wang
  • , Jing Jie Zhang
  • , Xun Song
  • , Chuen Fai Ku
  • , Juan Zou
  • , Ji Xin Li
  • , Li Jun Rong
  • , Lu Tai Pan*
  • , Hongjie Zhang*
  • *Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

18 Citations (Scopus)
71 Downloads (Pure)

Abstract

Henrin A (1), a new ent-kaurane diterpene, was isolated from the leaves of Pteris henryi. The chemical structure was elucidated by analysis of the spectroscopic data including one-dimensional (1D) and two-dimensional (2D) NMR spectra, and was further confirmed by X-ray crystallographic analysis. The compound was evaluated for its biological activities against a panel of cancer cell lines, dental bacterial biofilm formation, and HIV. It displayed anti-HIV potential with an IC50 value of 9.1 µM (SI = 12.2).

Original languageEnglish
Pages (from-to)27978-27987
Number of pages10
JournalInternational Journal of Molecular Sciences
Volume16
Issue number11
DOIs
Publication statusPublished - 24 Nov 2015

User-Defined Keywords

  • Anti-HIV activity
  • Bioactivity evaluation
  • Ent-kaurane diterpene
  • Henrin A
  • Pteris henryi

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