Henrin A: A new anti-HIV Ent-kaurane diterpene from Pteris henryi

Wan Fei Li, Juan Wang, Jing Jie Zhang, Xun Song, Chuen Fai KU, Juan Zou, Ji Xin Li, Li Jun Rong, Lu Tai Pan*, Hongjie ZHANG

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Henrin A (1), a new ent-kaurane diterpene, was isolated from the leaves of Pteris henryi. The chemical structure was elucidated by analysis of the spectroscopic data including one-dimensional (1D) and two-dimensional (2D) NMR spectra, and was further confirmed by X-ray crystallographic analysis. The compound was evaluated for its biological activities against a panel of cancer cell lines, dental bacterial biofilm formation, and HIV. It displayed anti-HIV potential with an IC50 value of 9.1 µM (SI = 12.2).

Original languageEnglish
Pages (from-to)27978-27987
Number of pages10
JournalInternational Journal of Molecular Sciences
Volume16
Issue number11
DOIs
Publication statusPublished - 24 Nov 2015

Scopus Subject Areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

User-Defined Keywords

  • Anti-HIV activity
  • Bioactivity evaluation
  • Ent-kaurane diterpene
  • Henrin A
  • Pteris henryi

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