Henrin A: A new anti-HIV Ent-kaurane diterpene from Pteris henryi

Wan Fei Li; Juan Wang; Jing Jie Zhang; Xun Song; Chuen Fai Ku; Juan Zou; Ji Xin Li; Li Jun Rong; Lu Tai Pan; Hongjie Zhang

doi:10.3390/ijms161126071

Henrin A: A new anti-HIV Ent-kaurane diterpene from Pteris henryi

Wan Fei Li, Juan Wang, Jing Jie Zhang, Xun Song, Chuen Fai Ku, Juan Zou, Ji Xin Li, Li Jun Rong, Lu Tai Pan^*, Hongjie Zhang^*

^*Corresponding author for this work

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Journal article › peer-review

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Abstract

Henrin A (1), a new ent-kaurane diterpene, was isolated from the leaves of Pteris henryi. The chemical structure was elucidated by analysis of the spectroscopic data including one-dimensional (1D) and two-dimensional (2D) NMR spectra, and was further confirmed by X-ray crystallographic analysis. The compound was evaluated for its biological activities against a panel of cancer cell lines, dental bacterial biofilm formation, and HIV. It displayed anti-HIV potential with an IC₅₀ value of 9.1 µM (SI = 12.2).

Original language	English
Pages (from-to)	27978-27987
Number of pages	10
Journal	International Journal of Molecular Sciences
Volume	16
Issue number	11
DOIs	https://doi.org/10.3390/ijms161126071 https://doi.org/10.3390/ijms161126071
Publication status	Published - 24 Nov 2015

Scopus Subject Areas

Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

User-Defined Keywords

Anti-HIV activity
Bioactivity evaluation
Ent-kaurane diterpene
Henrin A
Pteris henryi

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title = "Henrin A: A new anti-HIV Ent-kaurane diterpene from Pteris henryi",

abstract = "Henrin A (1), a new ent-kaurane diterpene, was isolated from the leaves of Pteris henryi. The chemical structure was elucidated by analysis of the spectroscopic data including one-dimensional (1D) and two-dimensional (2D) NMR spectra, and was further confirmed by X-ray crystallographic analysis. The compound was evaluated for its biological activities against a panel of cancer cell lines, dental bacterial biofilm formation, and HIV. It displayed anti-HIV potential with an IC50 value of 9.1 µM (SI = 12.2).",

keywords = "Anti-HIV activity, Bioactivity evaluation, Ent-kaurane diterpene, Henrin A, Pteris henryi",

author = "Li, {Wan Fei} and Juan Wang and Zhang, {Jing Jie} and Xun Song and Ku, {Chuen Fai} and Juan Zou and Li, {Ji Xin} and Rong, {Li Jun} and Pan, {Lu Tai} and Hongjie Zhang",

note = "Funding information: The work described in this paper was collaborative efforts within multi-disciplinary cooperative programs supported by grants from by the Natural Science Foundation Committee of China (81160496), the Science and Technology Fund of Guizhou Province (No. [2009]2145), the Research Grants Council of the Hong Kong Special Administrative Region, China (Project No. HKBU 262912 and HKBU12103014), HKBU Interdisciplinary Research Matching Scheme (RC-IRMS/12-13/03), and Faculty Research Grants, Hong Kong Baptist University (FRG2/14-15/047 and FRG1/13-14/029). Publisher copyright: {\textcopyright} 2015 by the authors; licensee MDPI, Basel, Switzerland.",

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language = "English",

volume = "16",

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AU - Wang, Juan

AU - Zhang, Jing Jie

AU - Song, Xun

AU - Ku, Chuen Fai

AU - Zou, Juan

AU - Li, Ji Xin

AU - Rong, Li Jun

AU - Pan, Lu Tai

AU - Zhang, Hongjie

N1 - Funding information: The work described in this paper was collaborative efforts within multi-disciplinary cooperative programs supported by grants from by the Natural Science Foundation Committee of China (81160496), the Science and Technology Fund of Guizhou Province (No. [2009]2145), the Research Grants Council of the Hong Kong Special Administrative Region, China (Project No. HKBU 262912 and HKBU12103014), HKBU Interdisciplinary Research Matching Scheme (RC-IRMS/12-13/03), and Faculty Research Grants, Hong Kong Baptist University (FRG2/14-15/047 and FRG1/13-14/029). Publisher copyright: © 2015 by the authors; licensee MDPI, Basel, Switzerland.

PY - 2015/11/24

Y1 - 2015/11/24

N2 - Henrin A (1), a new ent-kaurane diterpene, was isolated from the leaves of Pteris henryi. The chemical structure was elucidated by analysis of the spectroscopic data including one-dimensional (1D) and two-dimensional (2D) NMR spectra, and was further confirmed by X-ray crystallographic analysis. The compound was evaluated for its biological activities against a panel of cancer cell lines, dental bacterial biofilm formation, and HIV. It displayed anti-HIV potential with an IC50 value of 9.1 µM (SI = 12.2).

AB - Henrin A (1), a new ent-kaurane diterpene, was isolated from the leaves of Pteris henryi. The chemical structure was elucidated by analysis of the spectroscopic data including one-dimensional (1D) and two-dimensional (2D) NMR spectra, and was further confirmed by X-ray crystallographic analysis. The compound was evaluated for its biological activities against a panel of cancer cell lines, dental bacterial biofilm formation, and HIV. It displayed anti-HIV potential with an IC50 value of 9.1 µM (SI = 12.2).

KW - Anti-HIV activity

KW - Bioactivity evaluation

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KW - Pteris henryi

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DO - 10.3390/ijms161126071

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Henrin A: A new anti-HIV Ent-kaurane diterpene from Pteris henryi

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