Halofuginone dually regulates autophagic flux through nutrient-sensing pathways in colorectal cancer

Keyphrases

• AMPK Pathway 10%
• Anti-colorectal Cancer 10%
• Anticancer Activity 10%
• ATG7 20%
• Autophagic 20%
• Autophagic Flux 100%
• Autophagosome Formation 10%
• Autophagy 40%
• Caloric Restriction 10%
• Cancer Growth 10%
• Chow Diet 10%
• Colorectal Cancer 100%
• Dietary Restriction 10%
• Dual Regulation 10%
• Dual Role 10%
• Gluconeogenesis 10%
• Glucose Metabolism 10%
• Glycolysis 10%
• Halofuginone 100%
• Liver Kinase B1 (LKB1) 10%
• Mammalian Target of Rapamycin (mTOR) 20%
• Metabolism 20%
• MTORC1 Signaling 10%
• Nutrient Sensing 100%
• Nutrient-poor 30%
• Nutrient-rich Conditions 30%
• Nutritional Condition 10%
• Phosphorylation Sites 20%
• Signaling Pathway 20%
• Standard Chow 10%
• Tumor Growth 10%
• Tumorigenesis 10%
• ULK1 20%
• Xenograft Mice 10%

Biochemistry, Genetics and Molecular Biology

• AMPK Signaling 25%
• Antineoplastic Activity 25%
• Autophagosome 25%
• Autophagy 100%
• Carcinogenesis 25%
• Downregulation 50%
• Gluconeogenesis 25%
• Glucose Metabolism 25%
• Mammalian Target of Rapamycin Complex 1 25%
• Metabolic Pathway 50%
• Protein Kinase B 50%
• Tumor Progression 25%
• ULK1 50%