TY - JOUR
T1 - Haemoglobin Mass and Running Time Trial Performance after Recombinant Human Erythropoietin Administration in Trained Men
AU - Durussel, Jérôme
AU - Daskalaki, Evangelia
AU - Anderson, Martin
AU - Chatterji, Tushar
AU - Wondimu, Diresibachew H.
AU - Padmanabhan, Neal
AU - Patel, Rajan K.
AU - McClure, John D.
AU - Pitsiladis, Yannis P.
N1 - Publisher copyright:
© 2013 Durussel et al.
PY - 2013/2/13
Y1 - 2013/2/13
N2 - Recombinant human erythropoietin (rHuEpo) increases haemoglobin mass (Hbmass) and maximal oxygen uptake (v̇ O2 max). Purpose: This study defined the time course of changes in Hbmass, v̇ O2 max as well as running time trial performance following 4 weeks of rHuEpo administration to determine whether the laboratory observations would translate into actual improvements in running performance in the field. Methods: 19 trained men received rHuEpo injections of 50 IU•kg-1 body mass every two days for 4 weeks. Hbmass was determined weekly using the optimized carbon monoxide rebreathing method until 4 weeks after administration. v̇ O2 max and 3,000 m time trial performance were measured pre, post administration and at the end of the study. Results: Relative to baseline, running performance significantly improved by ~6% after administration (10:30±1:07 min:sec vs. 11:08±1:15 min:sec, p<0.001) and remained significantly enhanced by ~3% 4 weeks after administration (10:46±1:13 min:sec, p<0.001), while v̇ O2 max was also significantly increased post administration (60.7±5.8 mL•min-1•kg-1 vs. 56.0±6.2 mL•min-1•kg-1, p<0.001) and remained significantly increased 4 weeks after rHuEpo (58.0±5.6 mL•min-1•kg-1, p = 0.021). Hbmass was significantly increased at the end of administration compared to baseline (15.2±1.5 g•kg-1 vs. 12.7±1.2 g•kg-1, p<0.001). The rate of decrease in Hbmass toward baseline values post rHuEpo was similar to that of the increase during administration (-0.53 g•kg-1•wk-1, 95% confidence interval (CI) (-0.68, -0.38) vs. 0.54 g•kg-1•wk-1, CI (0.46, 0.63)) but Hbmass was still significantly elevated 4 weeks after administration compared to baseline (13.7±1.1 g•kg-1, p<0.001). Conclusion: Running performance was improved following 4 weeks of rHuEpo and remained elevated 4 weeks after administration compared to baseline. These field performance effects coincided with rHuEpo-induced elevated v̇ O2 max and Hbmass.
AB - Recombinant human erythropoietin (rHuEpo) increases haemoglobin mass (Hbmass) and maximal oxygen uptake (v̇ O2 max). Purpose: This study defined the time course of changes in Hbmass, v̇ O2 max as well as running time trial performance following 4 weeks of rHuEpo administration to determine whether the laboratory observations would translate into actual improvements in running performance in the field. Methods: 19 trained men received rHuEpo injections of 50 IU•kg-1 body mass every two days for 4 weeks. Hbmass was determined weekly using the optimized carbon monoxide rebreathing method until 4 weeks after administration. v̇ O2 max and 3,000 m time trial performance were measured pre, post administration and at the end of the study. Results: Relative to baseline, running performance significantly improved by ~6% after administration (10:30±1:07 min:sec vs. 11:08±1:15 min:sec, p<0.001) and remained significantly enhanced by ~3% 4 weeks after administration (10:46±1:13 min:sec, p<0.001), while v̇ O2 max was also significantly increased post administration (60.7±5.8 mL•min-1•kg-1 vs. 56.0±6.2 mL•min-1•kg-1, p<0.001) and remained significantly increased 4 weeks after rHuEpo (58.0±5.6 mL•min-1•kg-1, p = 0.021). Hbmass was significantly increased at the end of administration compared to baseline (15.2±1.5 g•kg-1 vs. 12.7±1.2 g•kg-1, p<0.001). The rate of decrease in Hbmass toward baseline values post rHuEpo was similar to that of the increase during administration (-0.53 g•kg-1•wk-1, 95% confidence interval (CI) (-0.68, -0.38) vs. 0.54 g•kg-1•wk-1, CI (0.46, 0.63)) but Hbmass was still significantly elevated 4 weeks after administration compared to baseline (13.7±1.1 g•kg-1, p<0.001). Conclusion: Running performance was improved following 4 weeks of rHuEpo and remained elevated 4 weeks after administration compared to baseline. These field performance effects coincided with rHuEpo-induced elevated v̇ O2 max and Hbmass.
UR - http://www.scopus.com/inward/record.url?scp=84873936500&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0056151
DO - 10.1371/journal.pone.0056151
M3 - Journal article
C2 - 23418527
AN - SCOPUS:84873936500
SN - 1932-6203
VL - 8
JO - PLoS ONE
JF - PLoS ONE
IS - 2
M1 - e56151
ER -
