TY - JOUR
T1 - Gut microbiota-bile acid crosstalk contributes to the rebound weight gain after calorie restriction in mice
AU - Li, Mengci
AU - Wang, Shouli
AU - Li, Yitao
AU - Zhao, Mingliang
AU - Kuang, Junliang
AU - Liang, Dandan
AU - Wang, Jieyi
AU - Wei, Meilin
AU - Rajani, Cynthia
AU - Ma, Xinran
AU - Tang, Yajun
AU - Ren, Zhenxing
AU - Chen, Tianlu
AU - Zhao, Aihua
AU - Hu, Cheng
AU - Shen, Chengxing
AU - Jia, Weiping
AU - Liu, Ping
AU - Zheng, Xiaojiao
AU - Jia, Wei
N1 - Funding Information:
This work was supported by the National Key R&D Program of China 2021YFA1301300 (W.J.) and the National Natural Science Foundation of China 82122012 (X.Z.), 81974073 (W.J.), and 31972935 (T.C.).
Publisher Copyright:
© The Author(s) 2022
PY - 2022/4/19
Y1 - 2022/4/19
N2 - Calorie restriction (CR) and fasting are common approaches to weight reduction, but the maintenance is difficult after resuming food consumption. Meanwhile, the gut microbiome associated with energy harvest alters dramatically in response to nutrient deprivation. Here, we reported that CR and high-fat diet (HFD) both remodeled the gut microbiota with similar microbial composition, Parabacteroides distasonis was most significantly decreased after CR or HFD. CR altered microbiota and reprogramed metabolism, resulting in a distinct serum bile acid profile characterized by depleting the proportion of non-12α-hydroxylated bile acids, ursodeoxycholic acid and lithocholic acid. Downregulation of UCP1 expression in brown adipose tissue and decreased serum GLP-1 were observed in the weight-rebound mice. Moreover, treatment with Parabacteroides distasonis or non-12α-hydroxylated bile acids ameliorated weight regain via increased thermogenesis. Our results highlighted the gut microbiota-bile acid crosstalk in rebound weight gain and Parabacteroides distasonis as a potential probiotic to prevent rapid post-CR weight gain.
AB - Calorie restriction (CR) and fasting are common approaches to weight reduction, but the maintenance is difficult after resuming food consumption. Meanwhile, the gut microbiome associated with energy harvest alters dramatically in response to nutrient deprivation. Here, we reported that CR and high-fat diet (HFD) both remodeled the gut microbiota with similar microbial composition, Parabacteroides distasonis was most significantly decreased after CR or HFD. CR altered microbiota and reprogramed metabolism, resulting in a distinct serum bile acid profile characterized by depleting the proportion of non-12α-hydroxylated bile acids, ursodeoxycholic acid and lithocholic acid. Downregulation of UCP1 expression in brown adipose tissue and decreased serum GLP-1 were observed in the weight-rebound mice. Moreover, treatment with Parabacteroides distasonis or non-12α-hydroxylated bile acids ameliorated weight regain via increased thermogenesis. Our results highlighted the gut microbiota-bile acid crosstalk in rebound weight gain and Parabacteroides distasonis as a potential probiotic to prevent rapid post-CR weight gain.
UR - http://www.scopus.com/inward/record.url?scp=85128348411&partnerID=8YFLogxK
U2 - 10.1038/s41467-022-29589-7
DO - 10.1038/s41467-022-29589-7
M3 - Journal article
C2 - 35440584
AN - SCOPUS:85128348411
SN - 2041-1723
VL - 13
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 2060
ER -