Gut microbiota and colorectal cancer metastasis

Zongmei Zheng; Xinxin Hou; Zhaoxiang Bian; Wei Jia; Ling Zhao

doi:10.1016/j.canlet.2022.216039

Gut microbiota and colorectal cancer metastasis

Zongmei Zheng, Xinxin Hou, Zhaoxiang Bian, Wei Jia^*, Ling Zhao^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

28 Citations (Scopus)

Abstract

Gut microbiota play critical roles in the development of colorectal cancer (CRC) metastasis, but the underlying mechanisms remain elusive. This review discusses the molecular mechanisms by which the gut microbiota contribute to a tumor-permissive microenvironment and facilitate malignant transformation and dissemination of tumor cells, thereby mediating CRC metastasis.

Original language	English
Article number	216039
Journal	Cancer Letters
Volume	555
Early online date	15 Dec 2022
DOIs	https://doi.org/10.1016/j.canlet.2022.216039
Publication status	Published - 28 Feb 2023

User-Defined Keywords

Colorectal cancer
Gut microbiota
Metastasis
Tumor microenvironment

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.canlet.2022.216039

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@article{18b77653d77e47a287892fe2cf649948,

title = "Gut microbiota and colorectal cancer metastasis",

abstract = "Gut microbiota play critical roles in the development of colorectal cancer (CRC) metastasis, but the underlying mechanisms remain elusive. This review discusses the molecular mechanisms by which the gut microbiota contribute to a tumor-permissive microenvironment and facilitate malignant transformation and dissemination of tumor cells, thereby mediating CRC metastasis.",

keywords = "Colorectal cancer, Gut microbiota, Metastasis, Tumor microenvironment",

author = "Zongmei Zheng and Xinxin Hou and Zhaoxiang Bian and Wei Jia and Ling Zhao",

note = "Funding Information: This work was sponsored by the Shanghai Rising-Star Program (No. 22QA1408700) and the National Natural Science Foundation of China (No. 82104955). Publisher Copyright: {\textcopyright} 2022 Elsevier B.V.",

year = "2023",

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day = "28",

doi = "10.1016/j.canlet.2022.216039",

language = "English",

volume = "555",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

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TY - JOUR

T1 - Gut microbiota and colorectal cancer metastasis

AU - Zheng, Zongmei

AU - Hou, Xinxin

AU - Bian, Zhaoxiang

AU - Jia, Wei

AU - Zhao, Ling

N1 - Funding Information: This work was sponsored by the Shanghai Rising-Star Program (No. 22QA1408700) and the National Natural Science Foundation of China (No. 82104955). Publisher Copyright: © 2022 Elsevier B.V.

PY - 2023/2/28

Y1 - 2023/2/28

N2 - Gut microbiota play critical roles in the development of colorectal cancer (CRC) metastasis, but the underlying mechanisms remain elusive. This review discusses the molecular mechanisms by which the gut microbiota contribute to a tumor-permissive microenvironment and facilitate malignant transformation and dissemination of tumor cells, thereby mediating CRC metastasis.

AB - Gut microbiota play critical roles in the development of colorectal cancer (CRC) metastasis, but the underlying mechanisms remain elusive. This review discusses the molecular mechanisms by which the gut microbiota contribute to a tumor-permissive microenvironment and facilitate malignant transformation and dissemination of tumor cells, thereby mediating CRC metastasis.

KW - Colorectal cancer

KW - Gut microbiota

KW - Metastasis

KW - Tumor microenvironment

UR - http://www.scopus.com/inward/record.url?scp=85144332178&partnerID=8YFLogxK

U2 - 10.1016/j.canlet.2022.216039

DO - 10.1016/j.canlet.2022.216039

M3 - Review article

C2 - 36528182

AN - SCOPUS:85144332178

SN - 0304-3835

VL - 555

JO - Cancer Letters

JF - Cancer Letters

M1 - 216039

ER -

Gut microbiota and colorectal cancer metastasis

Abstract

User-Defined Keywords

UN SDGs

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