TY - JOUR
T1 - Guidongnins I–J
T2 - Two New 6,7-seco-7,20-Olide-ent-kaurene
Diterpenes with Unusual Structures from Isodon rubescens
AU - Zou, Juan
AU - Ye, Jianghai
AU - Zhao, Chenliang
AU - Zhang, Jingjie
AU - Liu, Yahua
AU - Pan, Lutai
AU - He, Kang
AU - Zhang, Hongjie
N1 - Funding Information:
This project was supported financially by the Natural-Scientific Research Program of Department of Education of Guizhou Province, Qianjiaoji [No (2023)070], National Natural Science Foundation of China (No 82204605), the Research Grants Council of the Hong Kong Special Administrative Region, China (Project No. 12102219), Hong Kong Baptist University, Research Committee, and University Grants Committee of the Hong Kong Special Administrative Region, China (UGC Research Matching Grant Scheme RMGS2019-1-19).
Publisher Copyright:
© 2023 by the authors.
PY - 2023/9
Y1 - 2023/9
N2 - Two undescribed ent-kaurene diterpenes, named guidongnins I (1) and J (2), were isolated from the medicinal plant Isodon rubescens. Compound 1 was determined to contain an unprecedented 23 carbons in the skeleton by bearing an extra isopropyl group at C-17 out of the diterpenoid parent structure, and compound 2 was the first example of 6,7-seco-7,20-olide-ent-kaurenes with two fused-tetrahydrofuran rings formed between C-6 and C-19/C-20 through oxygen bridges. Their structures, including their absolute configurations, were determined using the analyses of the spectroscopic and X-ray diffraction data. Guidongnins I (1) and J (2) were assessed for their anti-cancer activities against the growth of various cancer cell lines, and 2 displayed cytotoxic potency against HepG2 at IC50 27.14 ± 3.43 μM.
AB - Two undescribed ent-kaurene diterpenes, named guidongnins I (1) and J (2), were isolated from the medicinal plant Isodon rubescens. Compound 1 was determined to contain an unprecedented 23 carbons in the skeleton by bearing an extra isopropyl group at C-17 out of the diterpenoid parent structure, and compound 2 was the first example of 6,7-seco-7,20-olide-ent-kaurenes with two fused-tetrahydrofuran rings formed between C-6 and C-19/C-20 through oxygen bridges. Their structures, including their absolute configurations, were determined using the analyses of the spectroscopic and X-ray diffraction data. Guidongnins I (1) and J (2) were assessed for their anti-cancer activities against the growth of various cancer cell lines, and 2 displayed cytotoxic potency against HepG2 at IC50 27.14 ± 3.43 μM.
KW - Isodon rubescens
KW - ent-kaurene diterpenoid
KW - isopropyl group
KW - anti-cancer
KW - plausible biosynthetic pathway
UR - http://www.scopus.com/inward/record.url?scp=85170348534&partnerID=8YFLogxK
U2 - 10.3390/ijms241713451
DO - 10.3390/ijms241713451
M3 - Journal article
C2 - 37686256
AN - SCOPUS:85170348534
SN - 1661-6596
VL - 24
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 17
M1 - 13451
ER -
