Gold-Catalyzed Direct Intermolecular Coupling of Ketones, Secondary Amines, and Alkynes: A Facile and Versatile Access to Propargylic Amines Containing a Quaternary Carbon Center

Ming Cheng; Qiang Zhang; Xiao Yu Hu; Bo Gang Li; Jian Xin Ji; Albert S.C. Chan

doi:10.1002/adsc.201000914

Gold-Catalyzed Direct Intermolecular Coupling of Ketones, Secondary Amines, and Alkynes: A Facile and Versatile Access to Propargylic Amines Containing a Quaternary Carbon Center

Ming Cheng
, Qiang Zhang
, Xiao Yu Hu
, Bo Gang Li
, Jian Xin Ji^*
, Albert S.C. Chan

^*Corresponding author for this work

Office of the President and Vice-Chancellor

Research output: Contribution to journal › Journal article › peer-review

71 Citations (Scopus)

Abstract

The first gold-catalyzed direct intermolecular coupling of ketones, secondary amines, and alkynes was achieved under mild and solvent-free conditions. The present methodology provides a promising and versatile tool for the construction of propargylic amines with a newly-formed quaternary carbon center.

Original language	English
Pages (from-to)	1274-1278
Number of pages	5
Journal	Advanced Synthesis and Catalysis
Volume	353
Issue number	8
DOIs	https://doi.org/10.1002/adsc.201000914
Publication status	Published - May 2011

User-Defined Keywords

alkynes
gold salts
ketones
propargylic amines
secondary amines

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10.1002/adsc.201000914

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@article{bf61428e89dc4326940159eb5f4316d7,

title = "Gold-Catalyzed Direct Intermolecular Coupling of Ketones, Secondary Amines, and Alkynes: A Facile and Versatile Access to Propargylic Amines Containing a Quaternary Carbon Center",

abstract = "The first gold-catalyzed direct intermolecular coupling of ketones, secondary amines, and alkynes was achieved under mild and solvent-free conditions. The present methodology provides a promising and versatile tool for the construction of propargylic amines with a newly-formed quaternary carbon center.",

keywords = "alkynes, gold salts, ketones, propargylic amines, secondary amines",

author = "Ming Cheng and Qiang Zhang and Hu, \{Xiao Yu\} and Li, \{Bo Gang\} and Ji, \{Jian Xin\} and Chan, \{Albert S.C.\}",

note = "National Science Foundation of China. Grant Number: 20802072 Publisher copyright: {\textcopyright} 2011 WILEY-VCH Verlag GmbH \& Co. KGaA, Weinheim",

year = "2011",

month = may,

doi = "10.1002/adsc.201000914",

language = "English",

volume = "353",

pages = "1274--1278",

journal = "Advanced Synthesis and Catalysis",

issn = "1615-4150",

publisher = "Wiley-VCH Verlag",

number = "8",

}

Gold-Catalyzed Direct Intermolecular Coupling of Ketones, Secondary Amines, and Alkynes: A Facile and Versatile Access to Propargylic Amines Containing a Quaternary Carbon Center. / Cheng, Ming; Zhang, Qiang; Hu, Xiao Yu et al.
In: Advanced Synthesis and Catalysis, Vol. 353, No. 8, 05.2011, p. 1274-1278.

Research output: Contribution to journal › Journal article › peer-review

TY - JOUR

T1 - Gold-Catalyzed Direct Intermolecular Coupling of Ketones, Secondary Amines, and Alkynes

T2 - A Facile and Versatile Access to Propargylic Amines Containing a Quaternary Carbon Center

AU - Cheng, Ming

AU - Zhang, Qiang

AU - Hu, Xiao Yu

AU - Li, Bo Gang

AU - Ji, Jian Xin

AU - Chan, Albert S.C.

PY - 2011/5

Y1 - 2011/5

N2 - The first gold-catalyzed direct intermolecular coupling of ketones, secondary amines, and alkynes was achieved under mild and solvent-free conditions. The present methodology provides a promising and versatile tool for the construction of propargylic amines with a newly-formed quaternary carbon center.

AB - The first gold-catalyzed direct intermolecular coupling of ketones, secondary amines, and alkynes was achieved under mild and solvent-free conditions. The present methodology provides a promising and versatile tool for the construction of propargylic amines with a newly-formed quaternary carbon center.

KW - alkynes

KW - gold salts

KW - ketones

KW - propargylic amines

KW - secondary amines

UR - https://www.scopus.com/pages/publications/79957539503

U2 - 10.1002/adsc.201000914

DO - 10.1002/adsc.201000914

M3 - Journal article

AN - SCOPUS:79957539503

SN - 1615-4150

VL - 353

SP - 1274

EP - 1278

JO - Advanced Synthesis and Catalysis

JF - Advanced Synthesis and Catalysis

IS - 8

ER -

Gold-Catalyzed Direct Intermolecular Coupling of Ketones, Secondary Amines, and Alkynes: A Facile and Versatile Access to Propargylic Amines Containing a Quaternary Carbon Center

Abstract

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