Glycoconjugates of gadolinium complexes for MRI applications

David A. Fulton; Elisa M. Elemento; Silvio Aime; Linda Chaabane; Mauro Botta; David Parker

doi:10.1039/b517997a

Glycoconjugates of gadolinium complexes for MRI applications

David A. Fulton, Elisa M. Elemento, Silvio Aime, Linda Chaabane, Mauro Botta, David Parker^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

86 Citations (Scopus)

Abstract

Examples of C-4 symmetric, medium MW conjugates incorporating 12 glucose or galactose groups linked via four dendritic wedges to a central Gd complex have been characterised; their enhanced relaxivity is interpreted in terms of effective motional coupling and large contributions from second sphere water molecules.

Original language	English
Pages (from-to)	1064-1066
Number of pages	3
Journal	Chemical Communications
Issue number	10
DOIs	https://doi.org/10.1039/b517997a
Publication status	Published - 8 Feb 2006

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title = "Glycoconjugates of gadolinium complexes for MRI applications",

abstract = "Examples of C-4 symmetric, medium MW conjugates incorporating 12 glucose or galactose groups linked via four dendritic wedges to a central Gd complex have been characterised; their enhanced relaxivity is interpreted in terms of effective motional coupling and large contributions from second sphere water molecules.",

author = "Fulton, {David A.} and Elemento, {Elisa M.} and Silvio Aime and Linda Chaabane and Mauro Botta and David Parker",

note = "We thank the EPSRC, the EC-networks, DiMI and EMIL, Bracco-Imaging (Milan) and COST Action D-18 for support. The contribution of Luigi Miragoli (Bracco Imaging s.p.a.) to the in vivo MRI experiments is gratefully acknowledged. Publisher copyright: {\textcopyright} The Royal Society of Chemistry 2006",

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AU - Fulton, David A.

AU - Elemento, Elisa M.

AU - Aime, Silvio

AU - Chaabane, Linda

AU - Botta, Mauro

AU - Parker, David

N1 - We thank the EPSRC, the EC-networks, DiMI and EMIL, Bracco-Imaging (Milan) and COST Action D-18 for support. The contribution of Luigi Miragoli (Bracco Imaging s.p.a.) to the in vivo MRI experiments is gratefully acknowledged. Publisher copyright: © The Royal Society of Chemistry 2006

PY - 2006/2/8

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N2 - Examples of C-4 symmetric, medium MW conjugates incorporating 12 glucose or galactose groups linked via four dendritic wedges to a central Gd complex have been characterised; their enhanced relaxivity is interpreted in terms of effective motional coupling and large contributions from second sphere water molecules.

AB - Examples of C-4 symmetric, medium MW conjugates incorporating 12 glucose or galactose groups linked via four dendritic wedges to a central Gd complex have been characterised; their enhanced relaxivity is interpreted in terms of effective motional coupling and large contributions from second sphere water molecules.

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JO - Chemical Communications

JF - Chemical Communications

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ER -

Glycoconjugates of gadolinium complexes for MRI applications

Abstract

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