Glyceollin, a soybean phytoalexin with medicinal properties

Tzi Bun Ng*, Xiu Juan Ye, Jack Ho Wong, Evandro Fei Fang, Yau Sang Chan, Wenliang Pan, Xiu Yun Ye*, Stephen Cho Wing Sze, Kalin Yanbo Zhang, Fang Liu, He Xiang Wang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

This review covers the biosynthesis of glyceollin and its biological activities including antiproliferative/antitumor action (toward B16 melanoma cells, LNCaP prostate cancer cells, and BG-1 ovarian cancer cells), anti-estrogenic action (through estrogen receptors α- and β-), antibacterial action (toward Erwinia carotovora, Escherichia coli, Bradyrhizobium japonicum, Sinorhizobium fredii ), antinematode activity, and antifungal activity (toward Fusarium solani, Phakospora pachyrhizi, Diaporthe phaseolorum, Macrophomina phaseolina, Sclerotina sclerotiorum, Phytophthora sojae, Cercospora sojina, Phialophora gregata, and Rhizoctonia solani). Other activities include insulinotropic action and attenuation of vascular contractions in rat aorta.
Original languageEnglish
Pages (from-to)59-68
Number of pages10
JournalApplied Microbiology and Biotechnology
Volume90
Issue number1
Early online date20 Feb 2011
DOIs
Publication statusPublished - Apr 2011
Externally publishedYes

User-Defined Keywords

  • Soybean
  • Phytoalexin
  • Glyceollin
  • Medisin

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