Ginsenoside Rg1 and Rb1, in combination with salvianolic acid B, play different roles in myocardial infarction in rats

Yanping Deng; Tingting Zhang; Fukang Teng; Defang Li; Feng Xu; Kenka Cho; Jinghua Xu; Jun Yin; Li Zhang; Qian Liu; Ming Yang; Wanying Wu; Xuan Liu; De An Guo; Baohong Jiang

doi:10.1016/j.jcma.2014.10.001

Ginsenoside Rg1 and Rb1, in combination with salvianolic acid B, play different roles in myocardial infarction in rats

Yanping Deng, Tingting Zhang, Fukang Teng, Defang Li, Feng Xu, Kenka Cho, Jinghua Xu, Jun Yin, Li Zhang, Qian Liu, Ming Yang, Wanying Wu, Xuan Liu, De An Guo, Baohong Jiang^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

22 Citations (Scopus)

Abstract

Background: The herb pair of Salvia miltiorrhiza and Panax notoginseng has widely been used for improving coronary and cerebral circulation in China. However, the exact contribution of the major active components of S. miltiorrhiza and P. notoginseng to cardioprotection is far from clear. In the present study, three representative ingredients, salvianolic acid B (SalB) from S. miltiorrhiza and ginsenoside Rg1 (Rg1) and ginsenoside Rb1 (Rb1) from P. notoginseng, were selected to elucidate the mechanism of the herb pair at the ingredient level. Methods: The purity of SalB, Rg1, and Rb1 was >99%, as detected by high-performance liquid chromatography. Acute myocardial infarction was introduced by ligation of the left anterior descending coronary artery near the main pulmonary artery. Cardiac contractility was detected through a Mikro-tipped catheter, and cardiac infarct size was determined using triphenyltetrazolium chloride stain. Results: The combination of SalB and Rg1, and not the combination of SalB and Rb1, improved heart contractility in rats with myocardial infarction. The different contributions of Rg1 and Rb1, in combination with SalB, to cardioprotection provides further direction to optimize and modernize the herbal medicines containing S. miltiorrhiza and P. notoginseng. Conclusion: The combination of SalB and Rg1 may provide potential protection against myocardial infarction.

Original language	English
Pages (from-to)	114-120
Number of pages	7
Journal	Journal of the Chinese Medical Association
Volume	78
Issue number	2
DOIs	https://doi.org/10.1016/j.jcma.2014.10.001
Publication status	Published - 1 Feb 2015

Scopus Subject Areas

General Medicine

User-Defined Keywords

Acute myocardial infarction
Ginsenoside Rb1
Ginsenoside Rg1
Panax notoginseng
Salvia miltiorrhiza
Salvianolic acid B

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jcma.2014.10.001

Cite this

Deng, Y., Zhang, T., Teng, F., Li, D., Xu, F., Cho, K., Xu, J., Yin, J., Zhang, L., Liu, Q., Yang, M., Wu, W., Liu, X., Guo, D. A., & Jiang, B. (2015). Ginsenoside Rg1 and Rb1, in combination with salvianolic acid B, play different roles in myocardial infarction in rats. Journal of the Chinese Medical Association, 78(2), 114-120. https://doi.org/10.1016/j.jcma.2014.10.001

@article{4105a9de5fd640b2942658438c7adbe1,

title = "Ginsenoside Rg1 and Rb1, in combination with salvianolic acid B, play different roles in myocardial infarction in rats",

abstract = "Background: The herb pair of Salvia miltiorrhiza and Panax notoginseng has widely been used for improving coronary and cerebral circulation in China. However, the exact contribution of the major active components of S. miltiorrhiza and P. notoginseng to cardioprotection is far from clear. In the present study, three representative ingredients, salvianolic acid B (SalB) from S. miltiorrhiza and ginsenoside Rg1 (Rg1) and ginsenoside Rb1 (Rb1) from P. notoginseng, were selected to elucidate the mechanism of the herb pair at the ingredient level. Methods: The purity of SalB, Rg1, and Rb1 was >99%, as detected by high-performance liquid chromatography. Acute myocardial infarction was introduced by ligation of the left anterior descending coronary artery near the main pulmonary artery. Cardiac contractility was detected through a Mikro-tipped catheter, and cardiac infarct size was determined using triphenyltetrazolium chloride stain. Results: The combination of SalB and Rg1, and not the combination of SalB and Rb1, improved heart contractility in rats with myocardial infarction. The different contributions of Rg1 and Rb1, in combination with SalB, to cardioprotection provides further direction to optimize and modernize the herbal medicines containing S. miltiorrhiza and P. notoginseng. Conclusion: The combination of SalB and Rg1 may provide potential protection against myocardial infarction.",

keywords = "Acute myocardial infarction, Ginsenoside Rb1, Ginsenoside Rg1, Panax notoginseng, Salvia miltiorrhiza, Salvianolic acid B",

author = "Yanping Deng and Tingting Zhang and Fukang Teng and Defang Li and Feng Xu and Kenka Cho and Jinghua Xu and Jun Yin and Li Zhang and Qian Liu and Ming Yang and Wanying Wu and Xuan Liu and Guo, {De An} and Baohong Jiang",

note = "Funding Information: This work was supported by the National Science and Technology Major Project for “Key New Drug Creation and Manufacturing Program” ( 2013ZX09103002-024 ), National Natural Science Foundation of China grants ( 81173587 ), and Shanghai Science and Technology Development Foundation ( 14401900900 ). This work was also partially supported by the 12 th 5-Year National Science and Technology Support Program ( 2012BAI29B06 ) and the National High Technology Research and Development Program (“863” Program) of China ( SS2013AA09002 ).",

year = "2015",

month = feb,

day = "1",

doi = "10.1016/j.jcma.2014.10.001",

language = "English",

volume = "78",

pages = "114--120",

journal = "Journal of the Chinese Medical Association",

issn = "1726-4901",

publisher = "Elsevier Taiwan LLC",

number = "2",

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TY - JOUR

T1 - Ginsenoside Rg1 and Rb1, in combination with salvianolic acid B, play different roles in myocardial infarction in rats

AU - Deng, Yanping

AU - Zhang, Tingting

AU - Teng, Fukang

AU - Li, Defang

AU - Xu, Feng

AU - Cho, Kenka

AU - Xu, Jinghua

AU - Yin, Jun

AU - Zhang, Li

AU - Liu, Qian

AU - Yang, Ming

AU - Wu, Wanying

AU - Liu, Xuan

AU - Guo, De An

AU - Jiang, Baohong

N1 - Funding Information: This work was supported by the National Science and Technology Major Project for “Key New Drug Creation and Manufacturing Program” ( 2013ZX09103002-024 ), National Natural Science Foundation of China grants ( 81173587 ), and Shanghai Science and Technology Development Foundation ( 14401900900 ). This work was also partially supported by the 12 th 5-Year National Science and Technology Support Program ( 2012BAI29B06 ) and the National High Technology Research and Development Program (“863” Program) of China ( SS2013AA09002 ).

PY - 2015/2/1

Y1 - 2015/2/1

N2 - Background: The herb pair of Salvia miltiorrhiza and Panax notoginseng has widely been used for improving coronary and cerebral circulation in China. However, the exact contribution of the major active components of S. miltiorrhiza and P. notoginseng to cardioprotection is far from clear. In the present study, three representative ingredients, salvianolic acid B (SalB) from S. miltiorrhiza and ginsenoside Rg1 (Rg1) and ginsenoside Rb1 (Rb1) from P. notoginseng, were selected to elucidate the mechanism of the herb pair at the ingredient level. Methods: The purity of SalB, Rg1, and Rb1 was >99%, as detected by high-performance liquid chromatography. Acute myocardial infarction was introduced by ligation of the left anterior descending coronary artery near the main pulmonary artery. Cardiac contractility was detected through a Mikro-tipped catheter, and cardiac infarct size was determined using triphenyltetrazolium chloride stain. Results: The combination of SalB and Rg1, and not the combination of SalB and Rb1, improved heart contractility in rats with myocardial infarction. The different contributions of Rg1 and Rb1, in combination with SalB, to cardioprotection provides further direction to optimize and modernize the herbal medicines containing S. miltiorrhiza and P. notoginseng. Conclusion: The combination of SalB and Rg1 may provide potential protection against myocardial infarction.

AB - Background: The herb pair of Salvia miltiorrhiza and Panax notoginseng has widely been used for improving coronary and cerebral circulation in China. However, the exact contribution of the major active components of S. miltiorrhiza and P. notoginseng to cardioprotection is far from clear. In the present study, three representative ingredients, salvianolic acid B (SalB) from S. miltiorrhiza and ginsenoside Rg1 (Rg1) and ginsenoside Rb1 (Rb1) from P. notoginseng, were selected to elucidate the mechanism of the herb pair at the ingredient level. Methods: The purity of SalB, Rg1, and Rb1 was >99%, as detected by high-performance liquid chromatography. Acute myocardial infarction was introduced by ligation of the left anterior descending coronary artery near the main pulmonary artery. Cardiac contractility was detected through a Mikro-tipped catheter, and cardiac infarct size was determined using triphenyltetrazolium chloride stain. Results: The combination of SalB and Rg1, and not the combination of SalB and Rb1, improved heart contractility in rats with myocardial infarction. The different contributions of Rg1 and Rb1, in combination with SalB, to cardioprotection provides further direction to optimize and modernize the herbal medicines containing S. miltiorrhiza and P. notoginseng. Conclusion: The combination of SalB and Rg1 may provide potential protection against myocardial infarction.

KW - Acute myocardial infarction

KW - Ginsenoside Rb1

KW - Ginsenoside Rg1

KW - Panax notoginseng

KW - Salvia miltiorrhiza

KW - Salvianolic acid B

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U2 - 10.1016/j.jcma.2014.10.001

DO - 10.1016/j.jcma.2014.10.001

M3 - Journal article

C2 - 25476150

AN - SCOPUS:84922692183

SN - 1726-4901

VL - 78

SP - 114

EP - 120

JO - Journal of the Chinese Medical Association

JF - Journal of the Chinese Medical Association

IS - 2

ER -

Ginsenoside Rg1 and Rb1, in combination with salvianolic acid B, play different roles in myocardial infarction in rats

Abstract

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