Ginsenoside-Rb1 as an anti-cancer therapeutic: abridged secondary publication

A. S. T. Wong; C. K. C. Wong

Ginsenoside-Rb1 as an anti-cancer therapeutic: abridged secondary publication

A. S. T. Wong^*, C. K. C. Wong

^*Corresponding author for this work

Department of Biology

Research output: Contribution to journal › Journal article › peer-review

3 Citations (Scopus)

Abstract

Recurrence of cancer despite chemotherapy is associated with high mortality. Cancer stem cells (CSCs) have been reported to possess properties of self-renewal, differentiation, and drug resistance that lead to tumorigenesis and chemoresistance. They are not eliminated by conventional chemotherapy owing to their distinct molecular signatures. Thus, understanding CSCs’ biology and targeting them are important.

Saponins have been shown to exhibit potent cytotoxic effects as chemotherapeutics. Ginsenoside-Rb1 isolated from ginseng (0.37%-0.5%) is a notable saponin. After being taken orally, about 70% of Rb1 is metabolised to 20-O-β-Dglucopyranosyl-20(S)-protopanaxadiol (compound K) by gut microbes. This metabolite can be readily absorbed into the blood and retained in the body.

Original language	English
Pages (from-to)	16-17
Number of pages	2
Journal	Hong Kong Medical Journal
Volume	26
Issue number	6
Publication status	Published - Dec 2020

Scopus Subject Areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

@article{bda2bd8167c94be99fdade9c4ce08ef2,

title = "Ginsenoside-Rb1 as an anti-cancer therapeutic: abridged secondary publication",

abstract = "Recurrence of cancer despite chemotherapy is associated with high mortality. Cancer stem cells (CSCs) have been reported to possess properties of self-renewal, differentiation, and drug resistance that lead to tumorigenesis and chemoresistance. They are not eliminated by conventional chemotherapy owing to their distinct molecular signatures. Thus, understanding CSCs{\textquoteright} biology and targeting them are important.Saponins have been shown to exhibit potent cytotoxic effects as chemotherapeutics. Ginsenoside-Rb1 isolated from ginseng (0.37%-0.5%) is a notable saponin. After being taken orally, about 70% of Rb1 is metabolised to 20-O-β-Dglucopyranosyl-20(S)-protopanaxadiol (compound K) by gut microbes. This metabolite can be readily absorbed into the blood and retained in the body.",

author = "Wong, {A. S. T.} and Wong, {C. K. C.}",

note = "Funding Information: This study was supported by the Health and Medical Research Fund, Food and Health Bureau, Hong Kong SAR Government (#11121191). The full report is available from the Health and Medical Research Fund website (https://rfs1.fhb.gov.hk/index.html). Publisher Copyright: {\textcopyright} 2020 Administering Institution and Hong Kong SAR Government",

year = "2020",

month = dec,

language = "English",

volume = "26",

pages = "16--17",

journal = "Hong Kong Medical Journal",

issn = "1024-2708",

publisher = "Hong Kong Academy of Medicine Press",

number = "6",

}

TY - JOUR

T1 - Ginsenoside-Rb1 as an anti-cancer therapeutic

T2 - abridged secondary publication

AU - Wong, A. S. T.

AU - Wong, C. K. C.

N1 - Funding Information: This study was supported by the Health and Medical Research Fund, Food and Health Bureau, Hong Kong SAR Government (#11121191). The full report is available from the Health and Medical Research Fund website (https://rfs1.fhb.gov.hk/index.html). Publisher Copyright: © 2020 Administering Institution and Hong Kong SAR Government

PY - 2020/12

Y1 - 2020/12

N2 - Recurrence of cancer despite chemotherapy is associated with high mortality. Cancer stem cells (CSCs) have been reported to possess properties of self-renewal, differentiation, and drug resistance that lead to tumorigenesis and chemoresistance. They are not eliminated by conventional chemotherapy owing to their distinct molecular signatures. Thus, understanding CSCs’ biology and targeting them are important.Saponins have been shown to exhibit potent cytotoxic effects as chemotherapeutics. Ginsenoside-Rb1 isolated from ginseng (0.37%-0.5%) is a notable saponin. After being taken orally, about 70% of Rb1 is metabolised to 20-O-β-Dglucopyranosyl-20(S)-protopanaxadiol (compound K) by gut microbes. This metabolite can be readily absorbed into the blood and retained in the body.

AB - Recurrence of cancer despite chemotherapy is associated with high mortality. Cancer stem cells (CSCs) have been reported to possess properties of self-renewal, differentiation, and drug resistance that lead to tumorigenesis and chemoresistance. They are not eliminated by conventional chemotherapy owing to their distinct molecular signatures. Thus, understanding CSCs’ biology and targeting them are important.Saponins have been shown to exhibit potent cytotoxic effects as chemotherapeutics. Ginsenoside-Rb1 isolated from ginseng (0.37%-0.5%) is a notable saponin. After being taken orally, about 70% of Rb1 is metabolised to 20-O-β-Dglucopyranosyl-20(S)-protopanaxadiol (compound K) by gut microbes. This metabolite can be readily absorbed into the blood and retained in the body.

UR - https://www.hkmj.org/abstracts/v26n6%20Suppl%208/toc.htm

UR - http://www.scopus.com/inward/record.url?scp=85100594593&partnerID=8YFLogxK

M3 - Journal article

C2 - 33504672

AN - SCOPUS:85100594593

SN - 1024-2708

VL - 26

SP - 16

EP - 17

JO - Hong Kong Medical Journal

JF - Hong Kong Medical Journal

IS - 6

ER -

Ginsenoside-Rb1 as an anti-cancer therapeutic: abridged secondary publication

Abstract

Scopus Subject Areas

UN SDGs

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